Approaches to kidney replacement therapies—opportunities and challenges
Frontiers in Cell and Developmental Biology, 2022 One out of seven people develop chronic kidney disease (CKD). When kidney function continues to decline, CKD patients may develop end-stage renal disease (ESRD, or kidney failure). More than 2 out of 1,000 adults develop ESRD and these patients must live
Biao Huang +9 more
doaj +1 more source
Transplantation of Neural Tissue: Quail–Chick Chimeras [PDF]
, 2013 Tissue transplantation is an important approach in developmental neurobiology to determine cell fate, to uncover inductive interactions required for tissue specification and patterning as well as to establish tissue competence and commitment. Avian species are among the favorite model systems for these approaches because of their accessibility and ...
Streit, A, Stern, CD
openaire +4 more sources
The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras [PDF]
Development, 2021 ABSTRACT Growing human organs in animals sounds like something from the realm of science fiction, but it may one day become a reality through a technique known as interspecies blastocyst complementation. This technique, which was originally developed to study gene function in development, involves injecting donor pluripotent stem cells ...
Canbin Zheng, Emily B. Ballard, Jun Wu
openaire +2 more sources
Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium
npj Regenerative Medicine, 2022 Sonic Hedgehog (Shh), secreted from gastric parietal cells, contributes to the regeneration of the epithelium. The recruitment of macrophages plays a central role in the regenerative process.
Jayati Chakrabarti +6 more
doaj +1 more source
Allograft and Xenograft Acceptance under FK‐506 and Other Immunosuppressant Treatment [PDF]
, 1993 We will focus on two issues, both involving, but not confined to FK-506: first, the meaning of the graft acceptance, which is, after all, the objective of immunosuppression for the transplant surgeon; and second, how to take the next great step of ...
Kahan B. D. +9 more
core +1 more source
Achieving permanent transplant tolerance via reverse chimeras in orthotopic liver transplantation
, 2022 Abstract The severe side-effects and toxicities associated with lifelong immunosuppression after organ transplantation necessitate the quest for immunological tolerance, it is a durable immunosuppression-free state in which the transplanted allograft functions well without chronic rejection occurrence, and there is no transplant tolerance ...
gaofeng Tang, huibo zhao, Guoyong Chen
openaire +1 more source
Interspecies Chimeric Barriers for Generating Exogenic Organs and Cells for Transplantation
Cell Transplantation, 2022 A growing need for organs and novel cell-based therapies has provided a niche for approaches like interspecies chimeras. To generate organs from one donor species in another host species requires techniques such as blastocyst complementation and gene ...
Phoebe Strell +3 more
doaj +1 more source
Interspecies chimeras as a platform for exogenic organ production and transplantation
Experimental Biology and Medicine, 2021 Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation.
Daniel J Garry, Mary G Garry
openaire +2 more sources
São Paulo Medical Journal, 2001 CONTEXT: Identification of Philadelphia chromosome or BCR/ABL gene rearrangement in chronic myeloid leukemia is important at diagnosis as well as after treatment.
Maria de Lourdes Lopes Ferrari Chauffaille +3 more
doaj +1 more source
Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
core +2 more sources