Results 91 to 100 of about 655,517 (311)

Improved GFR and renal plasma perfusion following remote ischaemic conditioning in a porcine kidney transplantation model

, 2012
Delayed graft function (DGF) complicates approximately 25% of kidney allografts donated after brain death (DBD). Remote ischaemic conditioning (rIC) involves brief, repetitive, ischaemia in a distant tissue in connection with ischaemia/reperfusion in the
Henrik Birn, Rikke Norregaard, Leuvenink, Henri, Bo M. Bibby, Jorgensen, Troels M., Krogstrup, Nicoline V., Moldrup, Ulla, Birn, Henrik, Anna K. Keller, Soendergaard, Peter, Leuvenink, Henri; id_orcid, Marcussen, Niels; id_orcid, Secher, Niels G., Ulla Moldrup, Troels M. Jorgensen, Pedersen, Michael, Krogstrup, Nicoline Valentina, Norregaard, Rikke, Keller, Anna K., Bibby, Bo Martin, Ostraat, Ernst O., Peter Soendergaard, Else Toennesen, Marcussen, Niels, Ravlo, Kristian, Nicoline V. Krogstrup, Ostraat, Ernst O, Bente Jespersen, Toennesen, Else, Jespersen, Bente, Kristian Ravlo, Niels Marcussen, Ernst O. Ostraat, Henri Leuvenink, Keller, Anna Krarup, Bibby, Bo M., Niels G. Secher, Michael Pedersen, Jorgensen, Troels M, Secher, Niels   +39 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Decitabine-Containing Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Intermediate- and High-Risk Myelodysplastic Syndrome/Acute Myeloid Leukemia: Potential Decrease in the Incidence of Acute Graft versus Host Disease

Cancer Management and Research, 2019
Qing Ya Wang,* Yuan Li,* Ze Yin Liang, Yue Yin, Wei Liu, Qian Wang, Yu Jun Dong, Yu Hua Sun, Wei Lin Xu, Han Yun Ren Department of Hematology, Peking University First Hospital, Peking University, Beijing, People’s Republic of China*These authors ...
Wang QY, Li Y, Liang ZY, Yin Y, Liu W, Wang Q, Dong YJ, Sun YH, Xu WL, Ren HY   +9 more
doaj  

Competing-risk outcomes after hematopoietic stem cell transplantation from the perspective of time-dependent effects

Haematologica, 2018
The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects.
Daniel Fuerst, Sandra Frank, Carlheinz Mueller, Dietrich W Beelen, Johannes Schetelig, Dietger Niederwieser, Jürgen Finke, Donald Bunjes, Nicolaus Kröger, Christine Neuchel, Chrysanthi Tsamadou, Hubert Schrezenmeier, Jan Beyersmann, Joannis Mytilineos   +13 more
doaj   +1 more source

Overcoming skin rejection in composite tissue allotransplantation [PDF]

, 2008
The application of composite tissue techniques is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the ...
Horner, B., Horner, R.
core  

Similar and Promising Outcomes in Lymphoma Patients Treated with Myeloablative or Nonmyeloablative Conditioning and Allogeneic Hematopoietic Cell Transplantation [PDF]

, 2008
We compared the outcomes of 141 consecutive patients who received allogeneic transplantation with either myeloablative (MA) or nonmyeloablative/reduced intensity (NMA) conditioning for non-Hodgkin and Hodgkin lymphoma at the University of Minnesota.
Brunstein, Claudio, Miller, Jeffrey S., MacMillan, Margaret, Weisdorf, Daniel J., DeFor, Todd E., Tomblyn, Marcie, Burns, Linda J.   +6 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Functional immune reconstitution after allogeneic hematopoietic stem cell transplantation in myeloablative and non-myeloablative conditioned patients

Scientific Reports
Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a treatment modality for several hematological and immune-driven diseases. A conditioning regimen precedes transplantation.
Patrick Terrence Brooks, Lia Minculescu, Rebecca Svanberg Teglgaard, Hans Jakob Hartling, Jose Antonio Salado-Jimena, Lone Smidstrup Friis, Brian Kornblit, Ida Schjødt, Søren Lykke Petersen, Niels Smedegaard Andersen, Susanne Dam Nielsen, Jens Lundgren, Hanne Vibeke Marquart, Lars Klingen Gjaerde, Henrik Sengeløv, Sisse Rye Ostrowski   +15 more
doaj   +1 more source

GSH Attenuates Organ Injury and Improves Function after Transplantation of Fatty Livers [PDF]

, 2010
Ischemia-reperfusion injury (IRI) is increased after transplantation of steatotic livers. Since those livers are increasingly used for transplantation, protective strategies must be developed. Reactive oxygen species (ROS) play a key role in hepatic IRI.
Jauch, Karl-Walter, S. Pratschke, U. Grützner, Gruetzner, U., Angele, M. K., F. Loehe, M. Bilzer, M.K. Angele, Tufman, A., Löhe, F., Schauer, R. J., Bilzer, M., Pratschke, S., A. Tufman, K.-W. Jauch, R.J. Schauer   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source