Results 71 to 80 of about 49,168 (311)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Unmanipulated Haploidentical Bone Marrow Transplantation and Posttransplantation Cyclophosphamide for Hematologic Malignancies after Myeloablative Conditioning

, 2013
Fifty patients with high-risk hematologic malignancies, underwent an unmanipulated haploidentical bone marrow transplantation (BMT), followed by posttransplantation high-dose cyclophosphamide (PT-CY): the myeloablative (MA) conditioning consisted of ...
Bregante, Stefania, Miglino, Maurizio, Bacigalupo A., Luchetti, Silvia, Luchetti S, Bregante S, Ghiso A, Gualandi F, Lamparelli, Teresa, Di Grazia C, Varaldo, Riccardo, Varaldo R, Raiola AM, Ballerini, Filippo, Van Lint MT, Geroldi, Simona, Dominietto, Alida, Ghiso, Anna, Dominietto A, Raiola, Anna Maria, Gualandi, Francesca, Geroldi S, Van Lint, Maria Teresa, Lamparelli T, Bacigalupo, Andrea, Ballerini F, Di Grazia, Carmen   +26 more
core   +1 more source

Impact of Hyperferritinemia on the Outcome of Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation for Lymphoid Malignancies [PDF]

, 2013
Hyperferritinemia has been associated with adverse outcomes after allogeneic hematopoietic cell transplantation (allo-HCT) with myeloablative conditioning. However, its characteristics and impact on the outcome in the reduced-intensity conditioning (RIC)
Martino Bofarull, Rodrigo, Sierra, Jorge, López-Anglada, Lucía, Pérez-Simón, José Antonio, Universitat Autònoma de Barcelona. Departament de Medicina, Fernández-Avilés, Francesc, Fernandez Aviles, Francesc, Garcia-Cadenas, Irene, Carreras, Enric, Valcárcel, David, López Corral, Lucía, Novelli, Silvana, Martino, Rodrigo, Garcia Cadenas, Irene, Piñana, José Luis, Rovira, Montserrat, Barba, Pere   +16 more
core   +1 more source

A novel conditioning regimen with pre-transplantation immunosuppression reduces the complication rates in hematopoietic stem cell transplantation in transfusion-dependent β-thalassemia

Stem Cell Research & Therapy
Background Allo-HSCT is a curative therapy for patients with transfusion-dependent thalassemia (TDT). The high incidence of transplant-related complications is becoming an obstacle to safe and effective unrelated donor (URD) transplantation.
Huaqing Yang, Xinyu Li, Liping Que, Han Chen, Liping Zhan, Dunhua Zhou, Yang Li, Shaofen Lin, Yin Wang, Xiaojun Wu, Xiawei Han, Zhengzhou Wu, Danping Zhong, Ke Huang, Honggui Xu, Jianpei Fang   +15 more
doaj   +1 more source

Cerebral Involvement of Hemophagocytic Lymphohistiocytosis in Griscelli Syndrome

Journal of Pediatric Research, 2019
Type II Griscelli Syndrome (GS) is caused by a mutation in the RAB27A gene and usually manifests with silvery-gray hair, immune deficiency and the development of hemophagocytic lymphohistiocytosis (HLH).
Ersin Töret, Yılmaz Ay, Serap Aksoylar, Tuba Hilkay Karapınar, Yeşim Oymak   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Allogeneic stem cell transplantation with reduced intensity conditioning for patients with adrenoleukodystrophy

Molecular Genetics and Metabolism Reports, 2019
Objective: The prognosis of adrenoleukodystrophy (ALD)with neurological involvement is generally dismal; however, allogeneic stem cell transplantation (SCT) is recognized as effective to stabilize or improve the clinical symptoms of ALD.
Koji Kato, Ryo Maemura, Manabu Wakamatsu, Ayako Yamamori, Motoharu Hamada, Shinsuke Kataoka, Atsushi Narita, Shunsuke Miwata, Yuko Sekiya, Nozomu Kawashima, Kyogo Suzuki, Kotaro Narita, Sayoko Doisaki, Hideki Muramatsu, Hirotoshi Sakaguchi, Kimikazu Matsumoto, Yuka Koike, Osamu Onodera, Makiko Kaga, Nobuyuki Shimozawa, Nao Yoshida   +20 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Optimization of the indications for allogeneic stem cell transplantation in Acute Myeloid Leukemia based on interactive diagnostic strategies

, 2011
The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder.
Hartwig, Maite, Zander, Axel R., Haferlach, Torsten, Fehse, Boris, Bacher, Ulrike, Kröger, Nicolaus   +5 more
core   +1 more source

Optimization of allogeneic transplant conditioning: not the time for dogma [PDF]

Leukemia, 2006
Numerous reduced-intensity conditioning regimens for allogeneic hematopoietic cell transplantation are currently being explored, primarily in older patients and in individuals with comorbid conditions who are not eligible for conventional myeloablative conditioning regimens. There is agreement that these approaches have reduced early transplant-related
H J, Deeg, M B, Maris, B L, Scott, E H, Warren   +3 more
openaire   +2 more sources