Results 101 to 110 of about 813,932 (302)

Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology. [PDF]

Cell Immunol, 2020
Alegre ML.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

MEDT 340 Immunology

, 1986
Course syllabus for MEDT 340 Immunology Course description: Introduces the basic concepts and terminology of the immune response including humoral and cellular immunity, immunogenetics, tumor and transplantation immunity, serology, and ...
Klingensmith, Phyllis M.
core  

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

The Journal of Clinical Investigation
Calcineurin inhibitors (CNIs) constitute the backbone of modern acute graft-versus-host disease (aGVHD) prophylaxis regimens but have limited efficacy in the prevention and treatment of chronic GVHD (cGVHD).
Yewei Wang, Md Ashik Ullah, Olivia G. Waltner, Shruti S. Bhise, Kathleen S. Ensbey, Christine R. Schmidt, Samuel R.W. Legg, Tomoko Sekiguchi, Ethan L. Nelson, Rachel D. Kuns, Nicole S. Nemychenkov, Erden Atilla, Albert C. Yeh, Shuichiro Takahashi, Julie R. Boiko, Antiopi Varelias, Bruce R. Blazar, Motoko Koyama, Simone A. Minnie, Andrew D. Clouston, Scott N. Furlan, Ping Zhang, Geoffrey R. Hill   +22 more
doaj   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

LAG3 regulates antibody responses in a murine model of kidney transplantation

The Journal of Clinical Investigation
Lymphocyte activation gene 3 (LAG3) is a coinhibitory receptor expressed by various immune cells. Although the immunomodulatory potential of LAG3 is being explored in cancer and autoimmunity, there is no information on its role after organ ...
Michael Nicosia, Ran Fan, Juyeun Lee, Gabriella All, Victoria Gorbacheva, José I. Valenzuela, Yosuke Yamamoto, Ashley Beavers, Nina Dvorina, William M. Baldwin III, Eduardo Chuluyan, Motoo Araki, Brian T. Gaudette, Robert L. Fairchild, Booki Min, Anna Valujskikh   +15 more
doaj   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Proceedings of the 30th annual congress of the international liver transplantation society

The 2025 Annual Congress of the International Liver Transplantation Society (ILTS), themed “Advancing Liver Transplantation: Embracing Innovation for the Future, ” was held May 28-31 in Singapore.
Syn, Nicholas, Kyaw, A Mi Mi, Rammohan, Ashwin, Wilson, Elizabeth A., Moral, Kenan, Chadha, Ryan, Khan, Mohammad Qasim, Tejedor, Marta, Magistri, Paolo, Alconchel, Felipe, Patel, Madhukar S., Di Maira, Tommaso, Shankar, Sadhana, Mathew, Johns S., Hakeem, Abdul Rahman, Mao, Shennen, Kathirvel, Manikandan, Magistri P., Wilson E. A., Chadha R., Shankar S., Kyaw A. M. M., Syn N., Tejedor M., Alconchel F., Mao S., Kathirvel M., Di Maira T., Rammohan A., Moral K., Patel M. S., Khan M. Q., Hakeem A. R., Mathew J. S.   +33 more
core   +1 more source