Results 121 to 130 of about 813,932 (302)

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Dual-fluorescence reporter-based assay for rapid quantitative evaluation of antiviral activity against Venezuelan equine encephalitis virus

Scientific Reports
Venezuelan equine encephalitis virus (VEEV) is a mosquito-borne alphavirus primarily infecting equines, causing severe illness or death. The virus can also infect humans causing severe neurological complications. There are no antivirals or human vaccines
Gabriel Augusto Pires de Souza, Rana Abdelnabi, Lorena Sanchez Felipe, Thibault Francken, Leni Van Eyck, Benjamin Van Loy, Thayara Morais Portal, Joana S. Silva, Nick Verheyen, Wim Smets, Pieter Leyssen, Aleksandra Siekierska, Bert Vanmechelen, Koert Stittelaar, Johan Neyts   +14 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Retinal transplant immunology and advancements

Several gaps and barriers remain for transplanting stem cells into the eye to treat ocular disease, especially diseases of the retina. While the eye has historically been considered immune privileged, recent thinking has identified the immune system as ...
Washington, Kia M., Miyagishima, Kiyoharu J., Su, An-Jey A., Greenwell, Thomas N., Perez, Victor L., Mousa, Hazem M., Reed, Amberlynn A.   +6 more
core   +1 more source

Evaluation of corneal transplantation [PDF]

, 1997
Editorial / comment on corneal ...
Coster, Douglas John
core  

Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease

JCI Insight
Adoptive transfer of immunoregulatory cells can prevent or ameliorate graft-versus-host disease (GVHD), which remains the main cause of nonrelapse mortality after allogeneic hematopoietic stem cell transplantation.
Nana Talvard-Balland, Marion Lambert, Mathieu F. Chevalier, Norbert Minet, Marion Salou, Marie Tourret, Armelle Bohineust, Idan Milo, Véronique Parietti, Thomas Yvorra, Gérard Socié, Olivier Lantz, Sophie Caillat-Zucman   +12 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Infectious Diseases in Transplantation—Report of the 20th Nantes Actualités Transplantation Meeting

, 2015
International audienceThe 20th Nantes Actualités Transplantation (NAT) meeting was held on June 11, 2015, and June 12, 2015. This year, the local organizing committee selected an update on infectious diseases in solid organ and hematopoietic stem cell ...
Haspot, Fabienne, Halary, Franck Albert
core   +1 more source

Guest Editorial: Comparative Immunology of Marine Mammals

, 2019
Il contributo in oggetto è il "Guest Editorial" che apre il "Research Topic" dall'omonimo titolo ("Comparative Immunology of Marine Mammals"), di prossima pubblicazione sulla Rivista "Frontiers in Immunology"
Sierra E, Criscitiello MF, Di Guardo G, Mazzariol S   +3 more
core   +1 more source

High-dimensional analysis of NK cells in kidney transplantation uncovers subsets associated with antibody-independent graft dysfunction

JCI Insight
Natural killer (NK) cells respond to diseased and allogeneic cells through NKG2A/HLA-E or killer cell immunoglobulin-like receptor (KIR)/HLA-ABC interactions.
Dan Fu Ruan, Miguel Fribourg, Yuko Yuki, Yeon-Hwa Park, Maureen P. Martin, Haocheng Yu, Geoffrey C. Kelly, Brian Lee, Ronaldo M. de Real, Rachel Lee, Daniel Geanon, Seunghee Kim-Schulze, Nicholas Chun, Paolo Cravedi, Mary Carrington, Peter S. Heeger, Amir Horowitz   +16 more
doaj   +1 more source