Results 121 to 130 of about 4,003,320 (313)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Unijna polityka w zakresie zewnętrznych stosunków w dziedzinie lotnictwa [PDF]
internetowy Kwartalnik Antymonopolowy i Regulacyjny, 2016 Artykuł dotyczy unijnej polityki w zakresie zewnętrznych stosunków w dziedzinie lotnictwa. Autor przedstawia jej genezę, w tym prawne i ekonomiczno-polityczne implikacje orzeczeń Europejskiego Trybunału Sprawiedliwości z dnia 5 listopada 2002 r.
Marian Bujnowski
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Transport and social exclusion in Western Sydney
, 2005 Improving transportation in Greater Western Sydney has been a long standing issue frequently raised by residents and community groups in this, the third most populous, urban region in Australia. But what does it mean, and how can it best be achieved, are
Hurni, Anne
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Espace populations sociétésFor some geographers, isolation and insularity are linked, so transport systems must compensate for the effects of insularity. Under these conditions, can transport systems open a new path to understanding insularity?
Anne-Clémence Duverger
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Seamless Transport: Case Study Compendium
, 2012 Member Countries of the International Transport Forum and International Organisations working in the field of transport were asked to submit examples of good practice in seamless transport as an input to Summit 2012. Fifty case studies were received from
International Transport Forum
core +2 more sources