Results 131 to 140 of about 4,003,320 (313)
How does negative triangularity mitigate ITG turbulence and transport?
Nuclear FusionImproved confinement in negative triangularity (NT) experiments is attributed to reduced fluxes driven by micro-turbulence. The physical mechanism of why thermal confinement improves in NT relative to PT is unknown.
Rameswar Singh +2 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Centralization and transport of critically ill pediatric patients
Frontiers in PediatricsBackgroundCaring for critically ill pediatric patients requires specialized expertise, centralized facilities, and efficient transport systems. The centralization of pediatric intensive care units in tertiary centers has enhanced clinical outcomes ...
Ryo Kamidani +3 more
doaj +1 more source
, 2017 On 10 April 2017, the Finnish Government decided to open passenger rail transport to competition. According to this decision, rail transport will be opened to competition in stages, relying on a concession contract model.
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Transporters involved in hepatobiliary transport of drugs.
Folia Pharmacologica Japonica, 2010 近年，ヒト肝臓において非常に多くのトランスポーターが同定・機能解析されるにつれて，トランスポーターの遺伝子多型や薬物間相互作用による機能変動が薬物動態に与える影響を明らかにするための臨床研究も続々と報告されてきている．それに伴い，異物解毒システムの中でのトランスポーターの重要性が広く認知されてきた．代謝によって消失すると考えられてきた薬物の中にも肝取り込みトランスポーターの基質が含まれていることが明らかとなり，取り込みトランスポーターの機能変動が薬物動態の変化につながる事例が複数報告されてきている．本稿では，ヒト肝臓に発現する主な薬物トランスポーターを紹介すると共に，これらの遺伝子多型・薬物間相互作用が薬物動態や薬効・副作用に与える影響について概説することを目指した．
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
What impact do EU environmental policies have on urban transport? [PDF]
, 2011 Urban transport policy is shaped by multiple factors. It can be influenced by local, regional, national or supranational actors. The role of the European Union in initiating urban transport policies is unclear and its impact little understood.
Cavoli, CM
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Geocarto InternationalMethane (CH4) is the second most abundant anthropogenic greenhouse gas after carbon dioxide (CO2), accounting for about 20% of global emissions. CH4 anthropogenic emission sources include landfills, oil and natural gas systems, agricultural activities ...
Nosiseko Mashiyi +2 more
doaj +1 more source