Results 161 to 170 of about 5,329 (286)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Land Use Planning and its Role in Transforming the Adelaide-Gawler Line into a Transit Corridor of Connected Transit Oriented Developments

, 2011
The 2010 30 Year Plan for Greater Adelaide (2010 30YPGA) is a milestone achievement in the planning of public transit networks for the Greater Adelaide metropolitan area because of its explicit strategy of intensifying development densities along the ...
Allan, Andrew
core  

Improvement of Service in the Supply Chains of Goods in the Transport Communication “Europe–Russia” Using the Transit Potential of the Kaliningrad Region [PDF]

, 2020
Elena Ivanovna Pavlova, E.V. Cherpakova, Irada Mamedova, N.V. Yakushina, E.V. Karlyavina   +4 more
openalex   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Role of Transit Amenities and Vehicle Characteristics in Building Transit Ridership: Amenities for Transit Handbook and The Transit Design Game Workbook

, 1999
This report consists of a Handbook and a Workbook. The Handbook identifies and describes passenger amenities and transit vehicle characteristics that attract ridership and explores how amenities may affect ridership.
Transportation Research Board, Project for Public Spaces, Incorporated   +1 more
core  

Assessing Bike-Transit Accessibility

Bicycles are a potential first-last mile mode that can augment the service area of public transit, yet it is difficult to fully account for bike-to-transit trips in planning and travel demand modeling processes.
Guensler, Randall, Passmore, Reid, Watkins, Kari   +2 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Enhancing Urban Mobility with Aerial Ropeway Transit (ART): Future Accessibility Impacts of Multimodal Transit Expansion Scenarios

Aerial ropeway transit (ART) systems are emerging alternatives to augment existing transit systems in congested cities in the Global South, especially in urban areas with limited transit coverage because of road width constraints or topography ...
Mukhopadhyay, Ayan, Pani, Agnivesh, Gupta, Ankit, Puppala, Harish, Dubey, Abhishek, Jha, Shreepati   +5 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source