Results 141 to 150 of about 5,329 (286)
, 2014 Accessibility emerges as the transportation performance measure that emphasizes the benefits to transportation system users and captures more than the speed of travel.
Zlatkovic, Milan +2 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Extending public transit accessibility models to recognise transfer location
, 2020 A longstanding issue for public transit agencies has been how to assess the performance of transit service including spatial service coverage to meet the transport needs of the community.
Chai, Jason, Lee, Jinwoo (Brian)
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Prospects of Development of the Transit Function of Georgia under the Conditions of Globalization [PDF]
Ovidius University Annals: Economic Sciences Series, 2017 The purpose of our research is to analyze the effectiveness of transit potential of Georgia forthe sustainable development of the country's economy in terms of globalization and to evaluate therole of transport infrastructure in the field of transport ...
Kavtaradze Medea, Bejanidze Natia
doaj
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Trans-Caspian International Transport Route Infrastructure Assessment Using Simulation Modelling
Transport and TelecommunicationThe Trans-Caspian International Transport Route (TITR) is one of the main transport corridors between China and Europe. It passes through the territory of Kazakhstan, as well as the countries of the South Caucasus, Turkey, and Iran, and contributes to ...
Zhumanov Azat +2 more
doaj +1 more source
Landlockedness, Infrastructure and Trade:New Estimates for Central Asian Countries [PDF]
This paper assesses the impact of internal infrastructure and landlockedness on Central Asian trade. The impact of landlockedness on Central Asian’s trade costs is split into several components, using a panel gravity equation estimated on a large sample ...
Céline CARRERE, Christopher GRIGORIOU
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Transit Policies and Potential Carbon Dioxide Emission Impacts
, 2012 Promoting transit has been a national strategic policy as part of the effort to relieve traffic congestion in China. However, such promotion also offers a great potential benefit in carbon dioxide (CO2) abatement, to which insufficient attention has been
He, Dongquan +2 more
core +1 more source