Results 131 to 140 of about 61,913 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Exploring shared e-scooter trip patterns and links to public transport service level

Multimodal Transportation
This paper explores how public transport and shared e-scooter travel interact. Trip end travel patterns of shared e-scooter users are explored in relation to Public Transport service levels. An index measuring transit service level is developed.
Graham Currie, Alexa Delbosc, Ryan Cox, Mahesha Jayawardhena, James Reynolds   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

New IDEAS for Transit: Transit IDEA Program Annual Report

, 2015
TRB’s Innovations Deserving Exploratory Analysis (IDEA) program has issued its New IDEAS for Transit: Transit IDEA Program Annual Report, which summarizes recent investigations conducted under the Transit IDEA program. The U.S.
Transportation Research Board
core   +2 more sources

PROSPECTS FOR INTERNATIONAL FREIGHT TRAFFIC ALONG THE NORTHERN SEA ROUTE

Север и рынок: формирование экономического порядка
The Northern Sea Route (NSR) serves as a vital route for Russia, driven by both economic demands and the need for industrial development in the Arctic. The country primarily uses the NSR to supply goods to its northern regions, with the route also used ...
Anna B. Nikolaeva
doaj   +1 more source

Teaching «International Logistics» in Kazakhstan

Farabi Journal of Social Sciences, 2016
The main idea of this article is about teaching of «International Logistics» subject in Kazakhstan. Kazakhstan is the largest country with no outlet to the sea.
a. Bekmuhametova
doaj  

Estimating light-rail transit peak-hour boarding based on accessibility at station and route levels in Wuhan, China

, 2017
Promoting public transit is a well-recognized policy for sustainable urban transport development. Transit demand analysis proves to be a challenging task in fast growing cities, partially due to the lack of reliable data and applicable techniques for ...
Liu, Xuejun, Xuejun Liu, Ming Zhang, Huang, Zhengdong, Zhengdong Huang, Zhang, Ming   +5 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The Role of Transit Amenities and Vehicle Characteristics in Building Transit Ridership: Amenities for Transit Handbook and The Transit Design Game Workbook

, 1999
This report consists of a Handbook and a Workbook. The Handbook identifies and describes passenger amenities and transit vehicle characteristics that attract ridership and explores how amenities may affect ridership.
Transportation Research Board, Project for Public Spaces, Incorporated   +1 more
core   +2 more sources

What hinders adoption of the electric bus in Canadian transit? Perspectives of transit providers

, 2017
There is increasing advocacy for the electrification of mobility choices to reduce transport related GHG emissions. Bus transit has been always considered a promising context for electric powertrain technologies.
Mohamed, Moataz, Pavlos Kanaroglou, Moataz Mohamed, Ferguson, Mark, Mark Ferguson, Kanaroglou, Pavlos   +5 more
core   +1 more source