Results 81 to 90 of about 73,715 (300)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Example of rational modal split in the transport network technical and economic issues

Forum Scientiae Oeconomia, 2014
In recent decades, almost all over the world, the issue of sustainable de- velopment has been strongly promoted in the transport policy. Initially, it applied chiefly to creating specific documents defining basic terms, for in- stance Brundtland Report (
Ireneusz Celiński, Grzegorz Sierpiński   +1 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Social exclusion and transport policy

, 2004
This paper is a review of social inclusion in the specification by central government of policy instruments for local government. It forms part of the scooping study on Accessibility and User Needs in Transport (AUNT) funded by the EPSRC Sustainable ...
Titheridge, H.
core  

FRAUDA DOCUMENTARĂ ÎN TRANSPORTUL MARITIM

EIRP Proceedings, 2007
The existence of the international trading, involving overseas cargo transport can not be imagined inthe absence of proper transport documents, amongst them Bill of Lading is by far the most important.The continuous increase of the goods speed which are ...
Florin Tudor
doaj  

E-Commerce in Ports

Promet (Zagreb), 2002
EDI (Electronic Data Interchange) and electronic businessshould be looked upon as a natural evolution in the internationaltrade and transport cycle. One of the principal reasonsfor starting to use EDI are the heaps of documents written,shifted, handled ...
Elen Twrdy, Evelin Vatovec Krmac
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cycling on the Verge? Exploring the Place of Utility Cycling in Contemporary New Zealand Transport Policy

, 2014
Efforts to increase cycling as a mode of transport (utility cycling) occur at central, regional and local levels of government through a range of supportive strategies, research, and guidelines.
Smith, Megan
core  

Documents Used in International Transport of Goods

, 2010
This paper deals with transport documents used in international transport of goods. The most important transport documents in each type of transport (road, ocean and river, railway and air) are introduced.
Ševčík, Jakub
core   +1 more source