Results 51 to 60 of about 907,456 (311)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Criteria-Based Selection of Cycling Infrastructure: Comparative Analysis of European Guidelines
Engineering ProceedingsDetermining suitable cycling infrastructure is essential for transport planners in European countries seeking to improve safety, promote sustainability, and encourage active travel.
Emese Makó +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Domestic transport cost reductions and firms’ export behaviour [PDF]
, 2009 Transport infrastructure investment reduces the cost of distance and enables firms to establish and maintain contacts over larger distances. Spain has developed an ambitious road building programme over the last decades, which has considerably reduced ...
Albarrán, Pedro +2 more
core +1 more source
Using city gates as a means of estimating ancient traffic flows [PDF]
, 2020 Despite the recent flurry of interest in various aspects of ancient urbanism, we still know little about how much traffic flowed in and out of ancient cities, in part because of problems with using commodities as proxies for trade.
Hanson, John W.
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Infrastructure, Competition Regimes and Air Transport Costs: Cross Country Evidence [PDF]
The relevance of transport costs has increased as liberalization continues to reduce artificial barriers to trade. Countries need to adopt policies to `get closer` to global markets.
Alejandro Micco, Tomas Serebrisky
core +3 more sources
Traffic planning in modern large cities Paris and Istanbul
Scientific ReportsThe enhancement of flexibility, energy efficiency, and environmental friendliness constitutes a widely acknowledged trend in the development of urban infrastructure. The proliferation of various types of transportation vehicles exacerbates the complexity
Yunus Emre Ayözen, Hakan İnaç
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source