Results 41 to 50 of about 907,456 (311)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
European Transport Research ReviewThis paper describes an approach for developing strategic cycle network planning tools. Based on our experience developing and deploying the Cycle Route Uptake and Scenario Estimation (CRUSE) Tool for Ireland, we outline the underlying methods, including
Robin Lovelace +8 more
doaj +1 more source
The reduction of geomagnetic data for the territory of Latvia to the epoch 2021.5
Geodesy and CartographyThe article describes the sources of geomagnetic data, the reduction of geomagnetic data for the territory of Latvia to the epoch 2021.5, the history of previous magnetic observations in Latvia, the information available in the State Geodetic Network ...
Lubova Sulakova, Janis Kaminskis
doaj +1 more source
Transport policy and health inequalities: a health impact assessment of Edinburgh's transport policy [PDF]
, 2003 Health impact assessment (HIA) can be used to examine the relationships between inequalities and health. This HIA of Edinburgh's transport policy demonstrates how HIA can examine how different transport policies can affect different population groupings ...
Conway, L. +4 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Project Spens - Sustainable Pavement for European New Member States
Communications, 2013 This paper represents the main results of work package 5 of the SPENS project (Sustainable Pavements for European New Member States) that was focused on assessment of the impact of roads on the environment and where the Faculty of Civil Engineering of ...
Daniela Durcanska +3 more
doaj +1 more source
European Transport Research Review, 2023 Background The availability of private vehicles with autonomous features is widespread nowadays. Various car manufacturers are providing attributes like collision warning, city automatic emergency braking, adaptive cruise control, pedestrian detection ...
Muhammad Tabish Bilal, Davide Giglio
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Machine Learning Prediction of Pavement Macrotexture from 3D Laser-Scanning Data
Applied SciencesPavement macrotexture, quantified by mean texture depth (MTD) and mean profile depth (MPD), is a critical parameter for road safety and performance. The traditional sand patch test is labor-intensive and slow, creating a bottleneck for modern pavement ...
Nagy Richard +2 more
doaj +1 more source