Results 31 to 40 of about 10,647 (213)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

SATELLITE MONITORING OF TRANSPORTATION INFRASTRUCTURE

Proceedings of the 14th International Workshop on Structural Health Monitoring, 2023
Harsh weather conditions caused by climate change and increased traffic loads can accelerate the aging process of core public infrastructure. Conventional condition assessment methods primarily rely on visual inspections conducted years apart, making it difficult to detect subtle, ongoing changes in performance resulting from structural deterioration ...
Ozkan, Istemi, Cusson, Daniel, Shaikh, Shahroz   +2 more
openaire   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Cycle route uptake and scenario estimation (CRUSE): an approach for developing strategic cycle network planning tools

European Transport Research Review
This paper describes an approach for developing strategic cycle network planning tools. Based on our experience developing and deploying the Cycle Route Uptake and Scenario Estimation (CRUSE) Tool for Ireland, we outline the underlying methods, including
Robin Lovelace, Joey Talbot, Eugeni Vidal-Tortosa, Hussein Mahfouz, Elaine Brick, Peter Wright, Gary O’Toole, Dan Brennan, Suzanne Meade   +8 more
doaj   +1 more source

The reduction of geomagnetic data for the territory of Latvia to the epoch 2021.5

Geodesy and Cartography
The article describes the sources of geomagnetic data, the reduction of geomagnetic data for the territory of Latvia to the epoch 2021.5, the history of previous magnetic observations in Latvia, the information available in the State Geodetic Network ...
Lubova Sulakova, Janis Kaminskis
doaj   +1 more source

Project Spens - Sustainable Pavement for European New Member States

Communications, 2013
This paper represents the main results of work package 5 of the SPENS project (Sustainable Pavements for European New Member States) that was focused on assessment of the impact of roads on the environment and where the Faculty of Civil Engineering of ...
Daniela Durcanska, Martin Decky, Roman Licbinsky, Jiri Huzlik   +3 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Machine Learning Prediction of Pavement Macrotexture from 3D Laser-Scanning Data

Applied Sciences
Pavement macrotexture, quantified by mean texture depth (MTD) and mean profile depth (MPD), is a critical parameter for road safety and performance. The traditional sand patch test is labor-intensive and slow, creating a bottleneck for modern pavement ...
Nagy Richard, Kristof Gyorgy Nagy, Mohammad Fahad   +2 more
doaj   +1 more source