Results 81 to 90 of about 535,728 (294)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Propagation and Depolarization of a Short Pulse of Light in Sea Water

Journal of Marine Science and Engineering, 2020
We present the results of a theoretical study of underwater pulse propagation. The vector radiative transfer equation (VRTE) underlies our calculations of the main characteristics of the scattered light field in the pulse.
Evgeniy E. Gorodnichev, Kirill A. Kondratiev, Alexandr I. Kuzovlev, Dmitrii B. Rogozkin   +3 more
doaj   +1 more source

Derivation of a one-way radiative transfer equation in random media

, 2016
We derive from first principles a one-way radiative transfer equation for the wave intensity resolved over directions (Wigner transform of the wave field) in random media.
Borcea, Liliana, Garnier, Josselin
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PREDICTION OF ATMOSPHERIC AIR POLLUTION BY EMISSIONS OF MOTOR TRANSPORT TAKING INTO ACCOUNT THE CHEMICAL TRANSFORMATION OF HARMFUL SUBSTANCES

Nauka ta progres transportu, 2017
Purpose. Development of 3D numerical models, which allow us to calculate air pollution process from road transport emissions based on chemical transformation of pollutants.
M. M. Biliaiev, O. S. Slavinska, R. V. Kyrychenko   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Theoretical formulation of phase space microbunching instability in the presence of intrabeam scattering for single-pass or recirculation accelerators

Physical Review Accelerators and Beams, 2020
Microbunching instability (MBI) has been one of the most challenging issues in designs of high-brightness beam transport lines for single-pass or recirculating accelerators.
Cheng-Ying Tsai, Weilun Qin, Kuanjun Fan, Xiaofan Wang, Juhao Wu, Guanqun Zhou   +5 more
doaj   +1 more source

On the theory of astronomical maser. I. Statistics of maser radiation

, 2009
In this paper we re-analyse the amplification process of broadband continuum radiation by astronomical masers in one-dimensional case. The basic equations appropriate for the scalar maser and the random nature of the maser radiation field are derived ...
Arechi, Born, Casperson, Champeney, Deguchi, Dinh-V-Trung, , Doob, Elitzur, Elitzur, Evans, Field, Field, Goldman, Goldreich, Gray, Icsevgi, Lamb, Litvak, Mandel, Menegozzi, Moran, Nedoluha, Press, Priestley, Rice, Rice, Root, Sargent, Sarma, Thompson, Watson, Watson, Western, Wiener, Yaglom, Yariv   +35 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source