Results 111 to 120 of about 5,385,238 (242)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Multimodal Freight Transport Planning: A Toolbox Supporting Stakeholders’ Collaboration
, 2019 This paper aims to analyse the planning of chemical transports’ shift from road to the more complex multimodal freight transport, and presents a toolbox developed to support the stakeholders in the process.
Cichosz, Marzenna; SGH Warsaw School of Economics, Department of Transport
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Concept of Freight Road-Railing Transport in Bimodal Technology [PDF]
, 2016 The article presents: the essence of bimodal transport, technical measures, technologies and setting bimodal trains in bimodal transport systems. Summary of the article is the analysis of advantages and disadvantages of road-rail freighttransport in ...
Mindur, Leszek; the International University of Logistics and Transport in Wrocław
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Animalsγ-aminobutyric acid (GABA), an inhibitory neurotransmitter, plays an important role in regulating stress responses through modulation of the hypothalamic–pituitary–adrenal axis, neuroendocrine activity, antioxidant defense, and immune function. Therefore,
Tao Chen, Meijuan Bai, Lizhi Wang
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Study of glucose homeostasis in burnout cases using an oral glucose tolerance test
StressBurnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes.
Anna-Karin Lennartsson +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Intercity passenger transport study
, 1971 Section 1 : A review of the status of the technology for tracked air cushion vehicles -- Section 2 : Linear induction motors as applicable to guided transport vehicles -- Section 3 : Propulsion of high speed ground transportation vehicles -- Section 4 ...
Canadian Transport Commission. Research Branch
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Program for Modelling Queuing Systems in Transport [PDF]
, 2012 This paper presents an example application of a software program developed using the programming language VBA and designed for modelling queuing systems in the field of transport.
Dimitrov, Stavri Dimitri; Todor Kableshkov University of Transport - Sofia
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source