Results 81 to 90 of about 5,385,238 (242)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leicester Transport Department, Humberstone Gate, 1970
, 1970 View of the roofs of the Leicester Transport Department ...
Calow, Dennis;
core +2 more sources
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Possibilities for Using NoSQL Databases in Information Systems in Transport [PDF]
, 2016 The article presents directions for development of end-user-oriented information systems in transport. Characteristics of databases belonging to the trend of NoSQL have been enumerated as well as the represented data models.The example of a relational ...
Czerepicki, Andrzej; Warsaw University of Technology, Faculty of Transport
core
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Bridging the divide : design’s role in improving multi-modal transport
, 2007 For a public transport user to experience an efficient journey, the transport system should demonstrate the network effect (Mees 2000; Nielsen et al. 2005); combining available modes in a network to achieve their best capacity.
Coxon, Selby +2 more
core
Research progress on livestock and poultry transport stress and its mitigation measures
Siliao yanjiuTransport stress is a non-specific physiological response caused by the long or long-distance transportation of animals, which can severely disrupt their physiological state, hormone secretion, and immune antioxidant functions, threaten their lives ...
CAO Tian-yu +7 more
doaj
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Veterinary SciencesHorse transport is considered a cause of stress in animals and is known to affect the 5-HT concentrations in both the brain and other tissues. The aim of this research was to investigate the effect of horse transportation and slaughter stress on plasma ...
Giuseppe Bruschetta +6 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source