Results 101 to 110 of about 500,302 (249)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Scenario analysis of HAZMAT transportation road traffic crashs on China's highways based on AcciNet-RFs. [PDF]
Sci RepDai Z, Fan R, Meng W, Chen Y, Tian S.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Retracted: A Novel Traffic Surveillance System Using an Uncalibrated Camera
Journal of Advanced Transportation, 2023 Journal of Advanced Transportation
doaj +1 more source
Robotic cell transportation system based on micropipette resistance modeling. [PDF]
Microsyst NanoengZhao Q +6 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Retracted: An Improved Deep Belief Network IDS on IoT-Based Network for Traffic Systems
Journal of Advanced Transportation, 2023 Journal of Advanced Transportation
doaj +1 more source