Results 121 to 130 of about 61,413 (308)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

0-6877 (Phase 2): Communications and Radar-Supported Transportation Operations and Planning (CAR-STOP) [Project Summary]

A recent report from the National Highway Traffic Safety Administration indicates that more than 80% of all annual car crashes could be prevented by vehicular communications.
Va, Vutha, Kumari, Preeti, Astroza, Sebastian, Heath, Robert W., Nair, Gopindra S, Ghosh, Joydeep, Oza, Saharsh, Prelcic, Nuria G., Motro, Michael, Bhat, Chandra R., Lavieri, Patricia S., Dias, Felipe F, Jensen, Darrin, Vinayak, Pragun, Ali, Anum, Kim, Taewan, Park, Jinsoo, University of Texas at Austin. Center for Transportation Research, Mondal, Aupal, Hutchinson, Joseph, Kalantari, Rahi   +20 more
core  

The 3D Gaussian Splatting SLAM System for Dynamic Scenes Based on LiDAR Point Clouds and Vision Fusion

Applied Sciences
This paper presents a novel 3D Gaussian Splatting (3DGS)-based Simultaneous Localization and Mapping (SLAM) system that integrates Light Detection and Ranging (LiDAR) and vision data to enhance dynamic scene tracking and reconstruction.
Yuquan Zhang, Guangan Jiang, Mingrui Li, Guosheng Feng   +3 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Private 5G Technology and Implementation Testing [PDF]

69A3551747115/06-006NEC developed a Video Analytics implementation for traffic intersections using 5G technology. This implementation included both hardware infrastructure and software applications supporting 5G communications, which allows low latency ...
Virginia Tech Transportation Institute, Mollenhauer, Michael A, White, Elizabeth E, Vilela, Jean Paul Talledo, Miller, Marty, Safety through Disruption (Safe-D) University Transportation Center (UTC)   +5 more
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Communications and radar-supported transportation operations and planning : final report. [PDF]

0-6877This project designs a conceptual framework to harness and mature wireless technology to improvetransportation safety, with a focus on frontal collision warning/collision avoidance (CW/CA) systems.
Kumari, Preeti, Heath, Robert W., Eltayeb, Mohammed, Ghosh, Joydeep, Motro, Michael, Nguyen, Duy H. N., Bhat, Chandra R., Lavieri, Patricia S., Ali, Anum, Kim, Taewan, Yeh, Enoch, Wang, Yuyang, University of Texas at Austin. Center for Transportation Research, Choi, Junil, Kalantari, Rahi   +14 more
core  

Media Messages and Tools to Reduce Serious Single Vehicle Run-Off-the-Road Crashes Resulting from Impaired Driving [PDF]

RP209The Center for Health and Safety Culture conducted research for the Idaho Transportation Department to develop media messages and tools to reduce fatalities and serious injuries related to Run-Off-the-Road, single-vehicle crashes in Idaho using the ...
Otto, Jay, Keller, Sarah, Ward, Nic, Linkenbach, Jeff W., Western Transportation Institute, Swinford, Steven   +5 more
core   +1 more source

A significant wave height prediction method combining VMD decomposition and the GVSAO-CNN-BiGRU-SA model

Frontiers in Marine Science
To improve the accuracy and robustness of significant wave height prediction under complex marine conditions, a multi-strategy Snow Ablation Optimization (GVSAO) model based on the Good Point Set Initialization Strategy (G), Cyclic Oscillation Mutation ...
Zongquan Ying, Zongquan Ying, Zongquan Ying, Wengeng Shen, Wengeng Shen, Wengeng Shen, Wengeng Shen, Xuegang Wang, Xuegang Wang, Xuegang Wang, Yiming Zhao, Yiming Zhao, Yiming Zhao, Meihong Lin, Meihong Lin, Meihong Lin   +15 more
doaj   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source