Results 91 to 100 of about 3,857,178 (370)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Demand responsive transit scheduling method considering passenger travel choice

Shenzhen Daxue xuebao. Ligong ban
Demand responsive transit service faces the challenge of maintaining operating profits while complying with passenger preferences. To address this, a multinomial logit model was established to describe passenger travel choice behaviors, and a service ...
SUN Jie, JIN Wenzhou, ZHANG Yong
doaj   +1 more source

Lessons Learned and Recommendations for the Application of Systems Engineering as an Emerging Discipline in Transportation & Infrastructure Projects [PDF]

, 2023
Oliver Hoehne
openalex   +1 more source

'Resilience thinking' in transport planning [PDF]

, 2015
Resilience has been discussed in ecology for over forty years. While some aspects of resilience have received attention in transport planning, there is no unified definition of resilience in transportation. To define resilience in transportation, I trace
Holling C. S., Jenelius E., Judith Y.T. Wang, Marsden G., Ortuzar J. D.   +4 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evaluation Method for Nighttime Visual Space Improvement on Mountain Roads

Zhongwai Gonglu
To address issues such as poor visual guidance, narrow field of view, and short sight distance during nighttime driving on mountain roads, this study proposed a visual space enhancement evaluation method applicable to mountainous roads at night.
ZHAO Yan, CHEN Yanli, CHEN Jiale
doaj   +1 more source

Groundwater Control Issues in Transportation Engineering: A Short Review of Dewatering Methods and Lessons Learned

, 2015
Areas that once were deemed unsuitable for construction due to a high water table are now being developed to meet the needs of an increasing population.
M. Angel, S. Johnston, K. O'Steen, Christopher Brown, T. Sando   +4 more
semanticscholar   +1 more source

Gap bootstrap methods for massive data sets with an application to transportation engineering [PDF]

, 2012
In this paper we describe two bootstrap methods for massive data sets. Naive applications of common resampling methodology are often impractical for massive data sets due to computational burden and due to complex patterns of inhomogeneity.
Appiah, J., Lahiri, S. N., Rilett, L., Spiegelman, C.   +3 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Three orbital transfer vehicles [PDF]

Aerospace engineering students at the Virginia Polytechnic Institute and State University undertook three design projects under the sponsorship of the NASA/USRA Advanced Space Design Program.

core   +1 more source