Results 81 to 90 of about 5,497,503 (307)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Innovative educational modules for the next generation of transportation professionals. [PDF]
DTRT06-G-0044Basic science and mathematics competence, including awareness of engineering careers, gained in grades K\u201312 forms the foundation of an educated, capable, and technical future transportation workforce.
Jasek, Debbie +3 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2010 application/pdf Title supplied by cataloger from file name. "January 20, 2010." Presentation to the Kansas Legislature, House Committee on Transportation, by staff of the Kansas Department of Transportation.
Kansas. Department of Transportation.
core
Formatting a questionnaire for the quality control of river bank roads
Open EngineeringThe quality control of road implementation on the rim and the strengthening of river edges to prevent road collapses need to be studied and developed continuously.
Salem Zahraa Amad, Ibraheem Asma Thamir
doaj +1 more source
Vehicle scheduling optimization for demand responsive transit with flexible stops
Shenzhen Daxue xuebao. Ligong banFlexible stops demand responsive transit is a public transportation mode that combines fixed service stops with the ability for passengers to book at flexible stops.
SHEN Zikang, JIN Wenzhou, ZHENG Yajing
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Demand distribution analysis and layout optimization for flex-route transit
Shenzhen Daxue xuebao. Ligong banThis work investigates the random distribution analysis of demand and layout adjustment for flex-route transit (FRT) based on historical data. Focusing on an FRT line with operational origin destination (OD) data, the study addresses demand uncertainty ...
GAN Junjie, PANG Mingbao, JIN Mingyue
doaj +1 more source