Results 91 to 100 of about 1,038,949 (301)
Three orbital transfer vehicles [PDF]
Aerospace engineering students at the Virginia Polytechnic Institute and State University undertook three design projects under the sponsorship of the NASA/USRA Advanced Space Design Program.
core +1 more source
Symmetry in Civil Transportation Engineering
SymmetrySymmetrical structures, such as tunnels, diaphragm walls, and blasting charge structures, are becoming increasingly prevalent in civil transportation engineering [...]
Yao Bai, Renliang Shan
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A Survey of Bridge Practitioners to Relate Damage to Closure [PDF]
, 2004 The Pacific Earthquake Engineering Research (PEER) Center's second-generation performance-based earthquake engineering (PBEE) methodology is intended in part to model highway bridge performance in terms of collapse, closure, repair duration, speed or ...
Porter, Keith A.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cargo transportation by airships: A systems study [PDF]
A systems engineering study of a lighter than air airship transportation system was conducted. The feasibility of the use of airships in hauling cargo was demonstrated.
Dalton, C., Huang, C. J.
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Journal of Highway and Transportation Research and DevelopmentSmart highway refers to a system that comprehensively applies new-generation information technologies to achieve digital, networked, and intelligent upgrades of highway infrastructure, thereby significantly enhancing efficiency, safety, and ...
Jian Gao +7 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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