Results 101 to 110 of about 140,962 (307)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

General Remarks in the Field of Transportation Engineering

, 1971
Yuichi NISHIMATSU
openalex   +2 more sources

Pavement-Transportation Computer Assisted Structural Engineering (PCASE) Implementation of the Modified Berggren (ModBerg) Equation for Computing the Frost Penetration Depth within Pavement Structures [PDF]

, 2012
Alessandra Bianchini, Carlos Ribas
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Comparative coal transportation costs: an economic and engineering analysis of truck, belt, rail, barge and coal slurry and pneumatic pipelines. Volume 1. Summary and conclusions. Final report

, 1977
Michael Rieber, S.L. Soo
openalex   +2 more sources

Microstation® Applications For Highway And Transportation Structures Design As Part Of The Software Series In Civil Engineering Technology Independent Learning Experiment [PDF]

, 2020
Nicholas Thomas, Ted Stilgenbauer, Anthony Brizendine   +2 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Analysis of research hotspots in oil & gas storage and transportation based on reports in Engineering Fronts and databases for retrieval

You-qi chuyun
Objective As energy transition progresses, oil & gas resources will remain vital as energy and chemical raw materials, significantly contributing to global economic recovery, the development of the new energy system, and the improvements of production ...
Zhaoyang LIU, Zhongyuan GUAN, Jiaxiong ZHAO, Peilu WU, Teng ZHANG, Mengyao QI   +5 more
doaj   +1 more source

Comparative coal transportation costs: an economic and engineering analysis of truck, belt, rail, barge and coal slurry and pneumatic pipelines. Volume 4. Barge transport. Final report

, 1977
Michael Rieber, S.L. Soo
openalex   +2 more sources

Innovative Techniques To Teach Transportation Engineering [PDF]

, 2020
Yusuf Mehta
openalex   +1 more source