Results 131 to 140 of about 1,021,622 (333)

Enhancing Transportation Education through On-line Simulation using an Agent-Based Demand and Assignment Model [PDF]

This research explores the effectiveness of using simulation as a tool for enhancing classroom learning in the Civil Engineering Department of the University of Minnesota at Twin Cities.
David Levinson, Feng Xie, Shanjiang Zhu
core  

I-11: Sustainable Supercorridor [PDF]

, 2015
Recently enacted Federal transportation legislation known as MAP-21 — Moving Ahead for Progress in the 21st Century — has brought renewed attention to a proposed interstate corridor connecting Las Vegas, Phoenix and Tucson, Arizona.
Samuels, L.C.
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

DOD/NASA system impact analysis (study 2.1). Volume 1: Executive summary [PDF]

Results are reported from a study made to determine engineering and cost analyses regarding the elements of space transportation systems. Specifically, a tug turnaround cost and abort modes and effects analyses were made.

core   +1 more source

Use of transportation relays to improve private fleet management [PDF]

, 2009
Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2009.Includes bibliographical references (leaf 53).We explore the use of transportation relays, a somewhat unconventional transportation operations ...
Agarwal, Mayank, Tsu, John
core  

A Flipped Classroom Approach to Teaching Transportation Engineering [PDF]

, 2016
Aliye Karabulut‐Ilgu, Suhan Yao, Peter T. Savolainen, Charles T. Jahren   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessing The Potential for Transportation Mode Switching in Mid-Sized Urban Areas using Binary Logistic Regression

Aceh International Journal of Science and Technology
Cities without public transport will suffer several issues, such as congestion, limited productive time, and a lower quality of life. The present study investigates various factors influencing public transportation choices in mid-sized urban, including ...
Said Basalim, Akhmadali Akhmadali
doaj   +1 more source