Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Algorithm Engineering for Realistic Journey Planning in Transportation Networks
, 2013 Thomas Pajor
openalex +1 more source
Application of gravity model for trip analysis in transportation and traffic engineering for Owerri Metropolis Nigeria [PDF]
, 2021 Obi Lawrence E
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Impact assessment using geographic information system (GIS): Transportation engineering applications
, 2019 Soon-tin Lim
openalex +1 more source
Review of Transportation Engineering FE2+: Introduction of Transportation to Civil Engineering Students by Ruey Long CheuBookBaby, Pennsauken Township, NJ, 08110; 2022; ISBN 9781667858784; 400 pp.; $64.96. [PDF]
, 2023 Rod E. Turochy
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Transportation engineering for enhanced production of plant natural products in microbial cell factories. [PDF]
Synth Syst BiotechnolZuo Y +5 more
europepmc +1 more source
Plasma-assisted physical vapor deposition surface treatments for tribological control [PDF]
In any mechanical or engineering system where contacting surfaces are in relative motion, adhesion, wear, and friction affect reliability and performance.
Spalvins, Talivaldis
core +1 more source