Results 51 to 60 of about 1,021,622 (333)

Work Organisation and Innovation - Case Study: Bombardier, Belgium [PDF]

open access: yes, 2013
[Excerpt] Bombardier Inc. is headquartered in Montréal, Canada and is structured around two businesses of almost the same size: aerospace and transportation. It has 76 production and engineering sites in more than 60 countries, and employs 65,400 people.
De Hauw, Yolien, Maenen, Seth
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Personal rapid transit and the future city with sustainable mobility

open access: yesJournal of Highway and Transportation Research and Development
The concept of personal rapid transit (PRT) has been proposed for over 70 years since 1953, and the practice of PRT has been advancing slowly worldwide. This paper analyzes advantages of PRT and applicable scenarios of PRT in the future city.
Jiaxiang Wang
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

IMPLEMENTATION OF POLICIES CONCERNING MANAGEMENT AND ENGINEERING OF TRAFFIC AND ROAD TRANSPORTATION AND PARKING IN UBUD SUB-DISTRICT

open access: yesE-Journal of Cultural Studies, 2023
Management and engineering of traffic and road transportation are programs initiated by the Gianyar Regency government with the aim of achieving an integrated transportation system that ensures safety, security, order, smoothness, regularity, success ...
I Made Artayasa
doaj   +1 more source

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