Results 51 to 60 of about 3,287,426 (295)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Data mining applications in transportation engineering [PDF]
Transport, 2003 Data mining is the extraction of implicit, previously unknown and potentially useful information from data. In recent time, data mining studies have been carried out in many engineering disciplines.
Sudhir Kumar Barai
doaj +2 more sources
, 2016 Acquiring and processing video streams from static cameras has been proposed as one of the most efficient tools for visualizing and gathering traffic information.
Emmanouil Barmpounakis +2 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Research on Soil Cutting with a Flat Cutter Using a Simulation Model
CommunicationsThe research aims to develop an algorithm for modelling the process of cutting an infinite volume of soil with a flat cutter in the Abaqus software package. The hypothesis of the existence of energy and volume of resistance to cutting is proposed.
Asset Altynbayev, Alexandr Ganyukov
doaj +1 more source
Handbook Of Transportation Engineering
, 2016 Thank you for downloading handbook of transportation engineering. Maybe you have knowledge that, people have look numerous times for their chosen books like this handbook of transportation engineering, but end up in infectious downloads.
Franziska Abend
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Sustainable CitiesIntroductionThis study presents the first comprehensive evaluation of the CO2 mitigation potential of the Haramain High-Speed Railway (HHR) system in Saudi Arabia.
Hafiz Abdul Wajid
doaj +1 more source