Results 71 to 80 of about 166,559,933 (303)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Adult trauma centers in Poland: where do we stand?

International Journal of Emergency Medicine
Background A trauma system based on trauma centers was established in Poland only at the beginning of the second decade of the century. The aim of this study was to quantitatively and comparatively assess the functioning of the trauma system in Poland ...
Tomasz Sanak, Jakub Nożewski, Mateusz Putowski, Aleksandra Załustowicz, Adam Burakowski, Klimek Józefowicz, Sylweriusz Kosiński   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Long-range transportation plan

, 2004
Cover title.; "Prepared by State of Connecticut, Department of Transportation, Bureau of Policy & Planning ... ; in cooperation with U.S. Department of Transportation, Federal Highway Administration and the Federal Transit Administration"--Table of ...
Connecticut. Dept. of Transportation.
core  

Outcomes of Urgent Interhospital Transportation for Extracorporeal Membrane Oxygenation Patients

Journal of Chest Surgery, 2022
Background: Extracorporeal membrane oxygenation (ECMO) can be used in patients with refractory cardiogenic shock or respiratory failure. In South Korea, the need for transporting ECMO patients is increasing.
Jun Tae Yang, Hyoung Soo Kim, Kun Il Kim, Ho Hyun Ko, Jung Hyun Lim, Hong Kyu Lee, Yong Joon Ra   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Maritime trade and transportation '99

The marine transportation system contributes to U.S. economic growth, enhances global competitiveness, and supports national security objectives.
United States. Department of Transportation. Bureau of Transportation Statistics
core   +1 more source

Ambulance traffic accidents and their impact on prehospital personnel: a mixed-methods study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Objective Prehospital personnel operate in environments with a significant risk of on-duty traffic accidents. We investigated the prevalence and characteristics of on-duty ambulance traffic accidents and explored how prehospital personnel perceive and ...
Marianne Winther, Oliver Beierholm Sørensen, Anne Craveiro Brøchner, Daniel Wittrock, Peter Martin Hansen, Jens Stubager Knudsen, Lisa Seest Nielsen, Signe Amalie Wolthers, Lars Bak Nielsen, Helle Collatz Christensen, Lotte Huniche, Søren Mikkelsen, Eva Laerkner   +12 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source