Results 81 to 90 of about 183,513 (265)

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Racing against time: Emergency ambulance dispatches and response times, a register-based study in Region Zealand, Denmark, 2013–2022

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background The global strain on Emergency Medical Services (EMS) is reflected in the increasing number of emergency ambulance dispatches. Shorter EMS response times have demonstrated some effect on very specific and rare conditions.
Josefine Tangen Jensen, Thea Palsgaard Møller, Stig Nikolaj Fasmer Blomberg, Annette Kjær Ersbøll, Helle Collatz Christensen   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Prehospital emergency medical services in Nepal: current status, challenges, and future directions

International Journal of Emergency Medicine
Background Nepal, a landlocked country in South Asia, is topographically diverse, consisting of mountains, hills, and plains (Terai). Geographic challenges impede EMS access, especially in remote, mountainous areas with substandard and deteriorated road ...
Sanjaya Karki, Ishan Sharma, Sagun Shrestha, Jasper Chell, Callum Bayliss, Ram Krishna Budhathoki, Sushma Thapaliya, Santosh Neupane, Praphul Kumar Jha, Vijay Chaudhary, Dhirendra Kumar Malla   +10 more
doaj   +1 more source

Transporting Patients through a Centralized Service

The American Journal of Nursing, 1962
Under the immediate supervision of the assistant supervisor of auxiliary personnel, the C.T.S. is an integral part of the nursing service department. In April 1955, we began the C.T.S. with a staff of 10 orderlies and one secretary. Equipped with three house phones, 13 patient carts, and 11 wheelchairs, approximately 200 calls requesting transportation
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Hidden disabilities in patients with autoimmune rheumatic disease: an invisible barrier to daily functioning and healthcare accessibility

EULAR Rheumatology Open
: Objectives: Patients with autoimmune rheumatic disease (ARD) frequently experience invisible yet disabling symptoms, including chronic pain, fatigue, mobility issues, sensory impairments, and cognitive dysfunction. These hidden disabilities can hinder
Faisal Parlindungan, Rudy Hidayat, Sumariyono Sumariyono, Suryo Anggoro Kusumo Wibowo, Anna Ariane, Johanda Damanik, Abirianty Priandani Araminta, Cindy Oey, Mitra Alparisa, Indra Saputra, Annisa Aulia Fitri, Rio Rialdi, Tamariska Evelyn   +12 more
doaj   +1 more source