Results 41 to 50 of about 904,615 (316)

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

eLife, 2023
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits.
Maurice A Petroccione, Lianna Y D'Brant, Nurat Affinnih, Patrick H Wehrle, Gabrielle C Todd, Shergil Zahid, Haley E Chesbro, Ian L Tschang, Annalisa Scimemi   +8 more
doaj   +1 more source

Support varieties for transporter category algebras [PDF]

, 2011
Let G be a finite group. Over any finite G-poset P we may define a transporter category as the corresponding Grothendieck construction. The classifying space of the transporter category is the Borel construction on the G-space BP, while the k-category ...
Xu, Fei
core  

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions [PDF]

, 2016
The expression of polyspecific membrane transporters is one important mechanism by which cells can obtain resistance to structurally different antibiotics and cytotoxic agents.

core   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

An international questionnaire highlights and supports the case for including girls in Creatine Transporter Deficiency research

Frontiers in Neuroscience
Over the last 15 years, significant progress has been made for Creatine Transporter Deficiency (CTD) patients, with increased awareness and visibility, better diagnosis, and improved care.
Carole Chehowah, Carole Chehowah, Audrey Mittelman, Vincent des Portes   +3 more
doaj   +1 more source

The solute transport and binding profile of a novel nucleobase cation symporter 2 from the honeybee pathogen Paenibacillus larvae

FEBS Open Bio, 2018
Here, we report that a novel nucleobase cation symporter 2 encoded in the genome of the honeybee bacterial pathogen Paenibacillus larvae reveals high levels of amino acid sequence similarity to the Escherichia coli and Bacillus subtilis uric acid and ...
Amanda J. Stoffer‐Bittner, Candace R. Alexander, Douglas W. Dingman, George S. Mourad, Neil P. Schultes   +4 more
doaj   +1 more source

Nephron‐Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na+ transport. Methods and Results To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of NOS3 were
Yang Gao, Deborah Stuart, Takamune Takahishi, Donald E. Kohan   +3 more
doaj   +1 more source

Identification of transporter genes from the fungal endophyte Neotyphodium lolii : this thesis is presented in partial fulfilment of the requirements for the degree of Master of Science (MSc) in Plant Biology at Massey University, Palmerston North, New Zealand / [PDF]

, 2006
Neotyphodium lolii is an endophytic fungus that lives in the pasture grass, Lolium perenne. They share a mutualistic symbiotic relationship. N. lolii lives out its life cycle within the plant and produces secondary metabolites, including alkaloids ...
Knox, Deborah Sian
core  

Lactate-proton co-transport and its contribution to interstitial acidification during hypoxia in isolated rat spinal roots [PDF]

, 1993
Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate.
Aronson, Assaf, Ballanyi, Beaudry, Bonanno, Cabantchik, Chester, Combs, de Hemptinne, Deuticke, Deuticke, Dubinsky, Edlund, Grinstein, Halestrap, Halestrap, Halestrap, Halestrap, Halestrap, Hansen, Imai, Johnson, Juel, Kraig, Krnjević, Kuhr, Marrannes, Mason, Mutch, Poole, Poole, Poole, Poole, Raley-Susman, Roos, Roth, Scheller, Schneider, Schneider, Smith, Spencer, Strupp, Trosper, Walsh, Walz, Walz   +45 more
core   +1 more source

Transportation and the Environment [PDF]

Annual Review of Environment and Resources, 2011
The growth of CO2-intensive transport, mobility and the impact of transport on the environment are reviewed. The recent global exponential growth in transport is unsustainable and must end unless the transport sector can decarbonize. The paper examines solutions for low-carbon transport systems; the behavioral options; possible demand reduction; the ...
Banister, D., Anderton, K., Bonilla, D., Givoni, M., Schwanen, T.   +4 more
openaire   +3 more sources