Results 41 to 50 of about 500,846 (269)
Pathophysiological power of improper tonic GABAA conductances in mature and immature models
Frontiers in Neural Circuits, 2013 High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
doaj +1 more source
Neuroglia, 2023 Astrocytes make up the predominant cell population among glial cells in the mammalian brain, and they play a vital role in ensuring its optimal functioning.
Shiksha Sharan +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Molecules, 2018 Equilibrative nucleoside transporters (ENTs) are polytopic membrane transporters responsible for the translocation of nucleosides, nucleobases—to a lesser extent—and nucleoside analog therapeutics across cellular membranes.
Rebba C. Boswell-Casteel +2 more
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Cadmium Accumulation in Cereal Crops and Tobacco: A Review
Agronomy, 2022 Cadmium (Cd) is a toxic heavy metal with no known biological function in plants and one of the most toxic substances released into the environment. Crops, such as rice, maize, wheat and tobacco are the major sources of Cd for humans. Cd toxicity inhibits
Shineng Mei +5 more
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Effect of energy sources and levels on caecal microbial population, jejunal morphology, gene expression of jejunal transporters (sglt1, fabp) and performance of broilers under heat stress [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017 The present study was conducted to evaluate the effects of energy sources and levels on microbial population, jejunal morphology, gene expression of glucose transporter (SGLT1), fatty acid binding protein (FABP) and performance in broilers under heat ...
GHAHREMANI A +4 more
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Plants, 2023 Macleaya cordata is a dominant plant of mine tailings and a zinc (Zn) accumulator with high Zn tolerance. In this study, M. cordata seedlings cultured in Hoagland solution were treated with 200 μmol·L−1 of Zn for 1 day or 7 days, and then, their leaves ...
Hongxiao Zhang +6 more
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To Transport or Not to Transport: Post‐Growth Avenues for Transport Infrastructure Planning
Journal of Critical Infrastructure PolicyAbstractPost‐growth literature has recently raised attention to the role of transport infrastructure planning in relation to global sustainability challenges and human wellbeing. Transport infrastructure can be a major obstacle to change, due to sunk costs, material intensity, and historical path dependencies.
Stefan Verweij +2 more
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source