Results 41 to 50 of about 636,269 (313)

Structure and Function of the Bacterial Heterodimeric ABC Transporter CydDC: Stimulation of the ATPase Activity by Thiol and Heme Compounds [PDF]

, 2014
In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ABC- type cysteine/glutathione (GSH) transporter, CydDC.
Xie, H, Poole, Robert K,, Nyathi, Yvonne, Booth, WI, Nyathi, Y, Bullough, PA, Booth, Wesley I., Xie, Hua, Postis, Vincent; id_orcid, Poole, R. K., Tzokov, Svetomir B., Booth, W.I., Postis, Vincent, Yamashita, M., Booth, W. I., Baldwin, SA, Tzokov, S, Baldwin, Stephen A., Bullough, Per A, Postis, V, Postis, V., Yamashita, Masao, Yamashita, M, Bullough, Per A., Tzokov, Svetomir, Shepherd, M., Poole, RK, Bullough, P.A., Xie, Hao, Bullough, P. A., Poole, Robert K, Poole, R.K., Booth, Wesley I, Nyathi, Y., Tzokov, S. B., Xie, H., Baldwin, Stephen A, Baldwin, S.A., Tzokov, SB, Baldwin, S. A., Shepherd, Mark, Tzokov, S.B., Shepherd, M   +42 more
core   +1 more source

Transport and transporters in the endoplasmic reticulum

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers.
CSALA, M., MARCOLONGO, P., LIZAK, B., SENESI, S., MARGITTAI, E., FULCERI, R., MAGYAR, J. E., BENEDETTI, A., BANHEGYI, G.   +8 more
openaire   +5 more sources

Awareness of Genetic Polymorphism in Drug Metabolizing Enzymes and Transporters May Promote Personalized Type 2 Diabetes Management [Response to Letter]

Diabetes, Metabolic Syndrome and Obesity, 2022
David M Williams,1 Jeffrey W Stephens1,2 1Department of Diabetes and Endocrinology, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 8NL, UK; 2Diabetes Research Group, Swansea University Medical School, Swansea University, Swansea ...
Williams DM, Stephens JW
doaj  

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source

Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics

Pharmaceutics
Background/Objectives: Cell-mediated and peptide-assisted delivery systems have emerged as powerful platforms at the intersection of chemistry, nanotechnology, and molecular medicine.
Eszter Erdei, Ruth Deme, Balázs Balogh, István M. Mándity   +3 more
doaj   +1 more source

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

eLife, 2023
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits.
Maurice A Petroccione, Lianna Y D'Brant, Nurat Affinnih, Patrick H Wehrle, Gabrielle C Todd, Shergil Zahid, Haley E Chesbro, Ian L Tschang, Annalisa Scimemi   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Nitrate transporters and peptide transporters

FEBS Letters, 2007
In higher plants, two types of nitrate transporters, NRT1 and NRT2, have been identified. In Arabidopsis, there are 53 NRT1 genes and 7 NRT2 genes. NRT2 are high‐affinity nitrate transporters, while most members of the NRT1 family are low‐affinity nitrate transporters.
Tsay, Yi-Fang, Chiu, Chi-Chou, Tsai, Chyn-Bey, Ho, Cheng-Hsun, Hsu, Po-Kai   +4 more
openaire   +2 more sources

Thermodynamics of the ATPase Cycle of GlcV, the Nucleotide-Binding Domain of the Glucose ABC Transporter of Sulfolobus solfataricus [PDF]

, 2006
ATP-binding cassette transporters drive the transport of substrates across the membrane by the hydrolysis of ATP. They typically have a conserved domain structure with two membrane-spanning domains that form the transport channel and two cytosolic ...
Schuurman-Wolters, Gea,, Pretz, Monika G., Tampé, Robert,, van der Does, Chris, Driessen, Arnold J. M., Albers, Sonja-Verena,, Tampe, Robert, Does, Chris van der,, Albers, Sonja-Verena, Schuurman-Wolters, Gea; id_orcid, Pretz, Monika G.,, Albers, Sonja Verena, Does, Chris van der, Schuurman-Wolters, Gea, Driessen, Arnold J.M.,   +14 more
core   +2 more sources

An international questionnaire highlights and supports the case for including girls in Creatine Transporter Deficiency research

Frontiers in Neuroscience
Over the last 15 years, significant progress has been made for Creatine Transporter Deficiency (CTD) patients, with increased awareness and visibility, better diagnosis, and improved care.
Carole Chehowah, Carole Chehowah, Audrey Mittelman, Vincent des Portes   +3 more
doaj   +1 more source