Results 21 to 30 of about 500,846 (269)

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

Golgi Metal Ion Homeostasis in Human Health and Diseases

Cells, 2022
The Golgi apparatus is a membrane organelle located in the center of the protein processing and trafficking pathway. It consists of sub-compartments with distinct biochemical compositions and functions.
Jie Li, Yanzhuang Wang
doaj   +1 more source

The Staphylococcus aureus CidA and LrgA Proteins Are Functional Holins Involved in the Transport of By-Products of Carbohydrate Metabolism

mBio, 2022
The Staphylococcus aureus cidABC and lrgAB operons encode members of a well-conserved family of proteins thought to be involved in programmed cell death (PCD).
Jennifer L. Endres, Sujata S. Chaudhari, Xinyan Zhang, Janani Prahlad, Shu-Qi Wang, Lily A. Foley, Sorin Luca, Jeffrey L. Bose, Vinai C. Thomas, Kenneth W. Bayles   +9 more
doaj   +1 more source

Nucleocytoplasmic Transport [PDF]

Science, 1996
Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
openaire   +3 more sources

Generation of boron-deficiency-tolerant tomato by overexpressing an <i>Arabidopsis thaliana</i> borate transporter <i>AtBOR1</i>

Frontiers in Plant Science, 2014
Nutrient deficiency in soil poses a widespread agricultural problem. Boron (B) is an essential micronutrient in plants, and its deficiency causes defects in both vegetative and reproductive growth in various crops in the field.
Shimpei eUraguchi, Shimpei eUraguchi, Shimpei eUraguchi, Yuichi eKato, Yuichi eKato, Hideki eHanaoka, Kyoko eMiwa, Kyoko eMiwa, Toru eFUJIWARA, Toru eFUJIWARA   +9 more
doaj   +1 more source

Amino Acid Transporters in Plant Cells: A Brief Review

Plants, 2020
Amino acids are not only a nitrogen source that can be directly absorbed by plants, but also the major transport form of organic nitrogen in plants. A large number of amino acid transporters have been identified in different plant species.
Guangzhe Yang, Qiuxing Wei, Hao Huang, Jixing Xia   +3 more
doaj   +1 more source

Transport and transporters in the endoplasmic reticulum

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers.
CSALA, M., MARCOLONGO, P., LIZAK, B., SENESI, S., MARGITTAI, E., FULCERI, R., MAGYAR, J. E., BENEDETTI, A., BANHEGYI, G.   +8 more
openaire   +5 more sources

Awareness of Genetic Polymorphism in Drug Metabolizing Enzymes and Transporters May Promote Personalized Type 2 Diabetes Management [Response to Letter]

Diabetes, Metabolic Syndrome and Obesity, 2022
David M Williams,1 Jeffrey W Stephens1,2 1Department of Diabetes and Endocrinology, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 8NL, UK; 2Diabetes Research Group, Swansea University Medical School, Swansea University, Swansea ...
Williams DM, Stephens JW
doaj  

Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics

Pharmaceutics
Background/Objectives: Cell-mediated and peptide-assisted delivery systems have emerged as powerful platforms at the intersection of chemistry, nanotechnology, and molecular medicine.
Eszter Erdei, Ruth Deme, Balázs Balogh, István M. Mándity   +3 more
doaj   +1 more source

Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

eLife, 2023
Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits.
Maurice A Petroccione, Lianna Y D'Brant, Nurat Affinnih, Patrick H Wehrle, Gabrielle C Todd, Shergil Zahid, Haley E Chesbro, Ian L Tschang, Annalisa Scimemi   +8 more
doaj   +1 more source