Results 21 to 30 of about 904,615 (316)

Growth and Overall Health of Patients with SLC13A5 Citrate Transporter Disorder

Metabolites, 2021
We were interested in elucidating the non-neurologic health of patients with autosomal recessive SLC13A5 Citrate Transporter (NaCT) Disorder. Multiple variants have been reported that cause a loss of transporter activity, resulting in significant ...
Tanya L. Brown, Kimberly L. Nye, Brenda E. Porter   +2 more
doaj   +1 more source

Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]

, 1996
The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk,, Brands, Jan Roel,, Driessen, Arnold J.M.,, Konings, Wil N.,, Poolman, Bert,, Putman, Monique,, Veen, Hendrik W. van,   +6 more
core   +1 more source

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Frontiers in Pharmacology, 2018
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated.
Zhenyan Hou, Zhenyan Hou, Lei Chen, Lei Chen, Pingfei Fang, Pingfei Fang, Hualin Cai, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Lingjuan Cao, Huande Li, Huande Li, Bikui Zhang, Bikui Zhang, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Frontiers in Cell and Developmental Biology, 2023
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa, Koichiro Susa, Koichiro Susa, Kenichi Kobayashi, Kenichi Kobayashi, Pierre Galichon, Pierre Galichon, Takuya Matsumoto, Takuya Matsumoto, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Navin R. Gupta, Navin R. Gupta, Navin R. Gupta, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane   +30 more
doaj   +1 more source

A Node-Expressed Transporter OsCCX2 Is Involved in Grain Cadmium Accumulation of Rice

Frontiers in Plant Science, 2018
Excessive cadmium (Cd) accumulation in grains of rice (Oryza sativa L.) is a risk to food security. The transporters in the nodes of rice are involved in the distribution of mineral elements including toxic elements to different tissues such as grains ...
Xiaohua Hao, Xiaohua Hao, Meng Zeng, Jian Wang, Zhongwen Zeng, Jiali Dai, Zijing Xie, Yuanzhu Yang, Yuanzhu Yang, Lianfu Tian, Lianfu Tian, Liangbi Chen, Dongping Li   +12 more
doaj   +1 more source

Structural basis for mammalian nucleotide sugar transport

eLife, 2019
Nucleotide-sugar transporters (NSTs) are critical components of the cellular glycosylation machinery. They transport nucleotide-sugar conjugates into the Golgi lumen, where they are used for the glycosylation of proteins and lipids, and they then ...
Shivani Ahuja, Matthew R Whorton
doaj   +1 more source

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

A zinc transporter gene required for development of the nervous system. [PDF]

, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo, Graham, David M, Keen, Carl L, Messerli, Mark A, Rucker, Robert B   +4 more
core   +1 more source

Transport Dynamics in a Glutamate Transporter Homologue [PDF]

Biophysical Journal, 2013
Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate binding sites become accessible to ...
Akyuz, Nurunisa, Altman, Roger, Blanchard, Scott, Boudker, Olga   +3 more
openaire   +3 more sources

Golgi Metal Ion Homeostasis in Human Health and Diseases

Cells, 2022
The Golgi apparatus is a membrane organelle located in the center of the protein processing and trafficking pathway. It consists of sub-compartments with distinct biochemical compositions and functions.
Jie Li, Yanzhuang Wang
doaj   +1 more source