Results 21 to 30 of about 636,269 (313)

Evidence for Active Uptake and Deposition of Si-based Defenses in Tall Fescue

Frontiers in Plant Science, 2017
Silicon (Si) is taken up from the soil as monosilicic acid by plant roots, transported to leaves and deposited as phytoliths, amorphous silica (SiO2) bodies, which are a key component of anti-herbivore defense in grasses.
Emma McLarnon, Simon McQueen-Mason, Ingo Lenk, Susan E. Hartley   +3 more
doaj   +1 more source

The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions

Pharmaceutics, 2020
This study was designed to develop and validate a 10 probe drug cocktail named “Dual Cocktail”, composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11 in rat and ...
Mihwa Kwon, Ji-Hyeon Jeon, Min-Koo Choi, Im-Sook Song   +3 more
doaj   +1 more source

Growth and Overall Health of Patients with SLC13A5 Citrate Transporter Disorder

Metabolites, 2021
We were interested in elucidating the non-neurologic health of patients with autosomal recessive SLC13A5 Citrate Transporter (NaCT) Disorder. Multiple variants have been reported that cause a loss of transporter activity, resulting in significant ...
Tanya L. Brown, Kimberly L. Nye, Brenda E. Porter   +2 more
doaj   +1 more source

The sugar transporter ZmSUGCAR1 of the Nitrate Transporter 1/Peptide Transporter family is critical for maize grain filling. [PDF]

, 2022
Maternal-to-filial nutrition transfer is central to grain development and yield. Nitrate Transporter 1/Peptide Transporter (NRT1-PTR)-type transporters typically transport nitrate, peptides and ions.
Yu, Miao, Koch, Karen E, Geiger, Dietmar, McCarty, Donald R, Hedrich, Rainer, Li, Xuexian, Wang, Tianyi, Wang, Jing, Suter, Marianne, Lai, Jinsheng, Zhong, Yanting, Ludewig, Uwe, Zhao, Haiming, Wang, Yi, Fastner, Astrid, Braun, David M, Wu, Wei-Hua, Zhang, Meiling, Jin, Weiwei, Yang, Bo, Liu, Peng, Rentsch, Doris, Song, Weibin   +22 more
core   +1 more source

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters

Frontiers in Pharmacology, 2018
Triptolide (TP), the main bioactive component of Tripterygium wilfordii Hook F, can cause severe hepatotoxicity. Isoliquiritigenin (ISL) has been reported to be able to protect against TP-induced liver injury, but the mechanisms are not fully elucidated.
Zhenyan Hou, Zhenyan Hou, Lei Chen, Lei Chen, Pingfei Fang, Pingfei Fang, Hualin Cai, Hualin Cai, Huaibo Tang, Yongbo Peng, Yang Deng, Lingjuan Cao, Lingjuan Cao, Huande Li, Huande Li, Bikui Zhang, Bikui Zhang, Miao Yan, Miao Yan   +18 more
doaj   +1 more source

ATP/ADP biosensor organoids for drug nephrotoxicity assessment

Frontiers in Cell and Developmental Biology, 2023
Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major limitation during drug development. Multi-segmented kidney organoids derived from human pluripotent stem cells may complement traditional cell culture and animal ...
Koichiro Susa, Koichiro Susa, Koichiro Susa, Kenichi Kobayashi, Kenichi Kobayashi, Pierre Galichon, Pierre Galichon, Takuya Matsumoto, Takuya Matsumoto, Takuya Matsumoto, Akitoshi Tamura, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Ken Hiratsuka, Navin R. Gupta, Navin R. Gupta, Navin R. Gupta, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Iman K. Yazdi, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Joseph V. Bonventre, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane, Ryuji Morizane   +30 more
doaj   +1 more source

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
core   +1 more source

A Node-Expressed Transporter OsCCX2 Is Involved in Grain Cadmium Accumulation of Rice

Frontiers in Plant Science, 2018
Excessive cadmium (Cd) accumulation in grains of rice (Oryza sativa L.) is a risk to food security. The transporters in the nodes of rice are involved in the distribution of mineral elements including toxic elements to different tissues such as grains ...
Xiaohua Hao, Xiaohua Hao, Meng Zeng, Jian Wang, Zhongwen Zeng, Jiali Dai, Zijing Xie, Yuanzhu Yang, Yuanzhu Yang, Lianfu Tian, Lianfu Tian, Liangbi Chen, Dongping Li   +12 more
doaj   +1 more source

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +2 more sources

Structural basis for mammalian nucleotide sugar transport

eLife, 2019
Nucleotide-sugar transporters (NSTs) are critical components of the cellular glycosylation machinery. They transport nucleotide-sugar conjugates into the Golgi lumen, where they are used for the glycosylation of proteins and lipids, and they then ...
Shivani Ahuja, Matthew R Whorton
doaj   +1 more source