Results 11 to 20 of about 904,615 (316)

Glucose Transport and Transporters in the Endomembranes [PDF]

International Journal of Molecular Sciences, 2019
Glucose is a basic nutrient in most of the creatures; its transport through biological membranes is an absolute requirement of life. This role is fulfilled by glucose transporters, mediating the transport of glucose by facilitated diffusion or by secondary active transport.
Beáta Lizák, András Szarka, Yejin Kim, Kyu-sung Choi, Csilla E. Németh, Paola Marcolongo, Angelo Benedetti, Gábor Bánhegyi, Éva Margittai   +8 more
openaire   +4 more sources

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Nature Communications, 2018
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for ...
Amanda J Scopelliti, Josep Font, Robert J Vandenberg, Olga Boudker, Renae M Ryan   +4 more
doaj   +1 more source

Modulation of Glycinergic Neurotransmission may Contribute to the Analgesic Effects of Propacetamol

Biomolecules, 2021
Treating neuropathic pain remains challenging, and therefore new pharmacological strategies are urgently required. Here, the enhancement of glycinergic neurotransmission by either facilitating glycine receptors (GlyR) or inhibiting glycine transporter ...
Lukas Barsch, Robert Werdehausen, Andreas Leffler, Volker Eulenburg   +3 more
doaj   +1 more source

Controlled functional expression of the bacteriocins pediocin PA-1 and bactofencin A in Escherichia coli [PDF]

, 2017
peer-reviewedThe bacteriocins bactofencin A (class IId) and pediocin PA-1 (class IIa) are encoded by operons with a similarly clustered gene organization including a structural peptide, an immunity protein, an ABC transporter and accessory bacteriocin ...
Cotter, Paul D., Hill, Colin, Mesa-Pereira, Beatriz, O’Connor, Paula M., Rea, Mary, Ross, R Paul   +5 more
core   +3 more sources

Nucleocytoplasmic Transport [PDF]

Science, 1996
Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
openaire   +3 more sources

Expression profiling of ascorbic acid–related transporters in human and mouse eyes [PDF]

, 2016
PURPOSE: Ascorbic acid (AsA) is an important antioxidant in the eye. Ascorbic acid is usually transported by sodium-dependent AsA transporters (SVCTs), and dehydroascorbic acid (DHA) by glucose transporters (GLUTs).
Beebe, David, Dana, Belinda, Huang, Andrew, Huang, Jie, Kubota, Miyuki, Liu, Margaret, Liu, Ying, Ma, Nan, Shui, Ying-Bo, Siegfried, Carla, Yan, Hong   +10 more
core   +2 more sources

Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats

Molecules, 2017
Our previous study showed that kurarinone was the main hepatotoxic ingredient of Sophora flavescens, accumulating in the liver. This study characterized the mechanism of Sophora flavescens extract (ESF) hepatotoxicity and hepatic accumulation of ...
Peng Jiang, Xiuwen Zhang, Yutong Huang, Nengneng Cheng, Yueming Ma   +4 more
doaj   +1 more source

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter [PDF]

, 2008
Multiple pathways link expression of PTR2, the transporter of di- and tripeptides in the yeast Saccharomyces cerevisiae, to the availability and quality of nitrogen sources.
Abdel-Sater, Abdel-Sater, Alagramam, Andréasson, Andréasson, Bachmair, Bernard, Boban, Boles, Byrd, Cai, Cai, Ditzel, Du, Fosberg, Frommer, Ghislain, Godard, Graciet, Holsbeeks, Homann, Hou, Hu, Hu, Hu, Inobe, Island, Johnson, Jorgensen, Klasson, Kwon, Kwon, Laney, Lee, Liu, Malavé, Mogk, Nielsen, Rao, Roosen, Sasaki, Schneider, Sikorski, Spielewoy, Suzuki, Tasaki, Tasaki, Tasaki, Turner, Turner, Varshavsky, Varshavsky, Varshavsky, Wiles, Wu, Xia, Xiao, Xie, Zenker   +58 more
core   +3 more sources

Evidence for Active Uptake and Deposition of Si-based Defenses in Tall Fescue

Frontiers in Plant Science, 2017
Silicon (Si) is taken up from the soil as monosilicic acid by plant roots, transported to leaves and deposited as phytoliths, amorphous silica (SiO2) bodies, which are a key component of anti-herbivore defense in grasses.
Emma McLarnon, Simon McQueen-Mason, Ingo Lenk, Susan E. Hartley   +3 more
doaj   +1 more source

The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions

Pharmaceutics, 2020
This study was designed to develop and validate a 10 probe drug cocktail named “Dual Cocktail”, composed of caffeine (Cyp1a2 in rat and CYP1A2 in human, 1 mg/kg), diclofenac (Cyp2c11 in rat and CYP2C9 in human, 2 mg/kg), omeprazole (Cyp2c11 in rat and ...
Mihwa Kwon, Ji-Hyeon Jeon, Min-Koo Choi, Im-Sook Song   +3 more
doaj   +1 more source