Results 81 to 90 of about 636,269 (313)

The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder [PDF]

, 2014
Dysfunction in the dopaminergic and serotonergic neurotransmitter systems has been demonstrated to be important in the etiology of borderline personality disorder (BPD).
Roger T Mulder, Patrick C Mchugh, Stephenson, John, Martin Kennedy, Roger T. Mulder, Joyce, Peter R., McHugh, Patrick C, Kennedy, Martin, Martin A Kennedy, Peter R Joyce, McHugh, Patrick C., Mulder, Roger T., John Stephenson, Patrick C. McHugh, Peter R. Joyce, John eStephenson   +15 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The transport disadvantaged — community transport or mainstream? [PDF]

Transportation Planning and Technology, 1995
This paper is based on a study undertaken for the New South Wales Department of Transport in 1991 to examine the cost of providing transport services for the aged and those with disabilities through the Community Transport program. A sample of Community Transport Projects in N.S.W. country and metropolitan areas was studied in detail and data collected
Battellino, Helen C., Hensher, David A.
openaire   +2 more sources

Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3 [PDF]

, 2004
Amino acids are regarded as the nitrogen ‘currency’ of plants. Amino acids can be taken up from the soil directly or synthesized from inorganic nitrogen, and then circulated in the plant via phloem and xylem.
Sakiko Okumoto, Leister, D., Frommer, Wolf B., Wolf B. Frommer, Okumoto, Sakiko, FISCHER, Wolf N, Stierhof, York Dieter, Frommer, W. B., Stierhof, Y., Stierhof, Y.-D., Fischer, W., Wolfgang Koch, Koch, W., FROMMER, Wolf B, Mechthild Tegeder, Fischer, Wolf N., Leister, Dario, Wolf N. Fischer, Koch, Wolfgang, Okumoto, S., Tegeder, Mechthild, Dario Leister, Tegeder, M., Biehl, A., York Dieter Stierhof, Alexander Biehl, Biehl, Alexander, Fischer, W. N., Frommer, W.   +28 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
Kabbara, S, Baune, B., Wang, T., Xu, X., McCarthy, P., Jaehne, E., Saleh, E., McClure, B., Woodcock, J., Wiszniak, S., Saleh, E, Schwarz, Q, McClure, B, Woodcock, J, McCarthy, P, Greenberg, Z, Kabbara, S., Wiszniak, S, Xu, X, Jaehne, EJ, van den Buuse, M., Wang, TY, Ramshaw, H., Schwarz, Q., Ramshaw, H, Lopez, A., Lopez, A, Baune, BT, Greenberg, Z., Parish, C., Van Den Buuse, M, Parish, C   +31 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea [PDF]

, 2009
The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development.
Pradier Jean-Marc, Pradier, J.M., Walker, Anne-Sophie, Mernke, Dennis, Pradier, Jean Marc, J. M., Leroux, Pierre, Matthias Hahn, Matthias Kretschmer, Sabine Fillinger, Walker, Anne Sophie, Kretschmer, M., Hahn, Matthias, Fillinger Sabine, Jean-Marc Pradier, Mosbach, Andreas, Walker, A.S., Mernke, Denis, Kretschmer Matthias, Mernke, D., Fillinger, S., de Waard, Maarten A, Maarten A De Waard, Walker, Anne Sophie, A. S., Leroux, P., de Waard, M.A., De Waard Maarten A., Leroux Pierre, Fillinger-David, Sabine, Helma, S. H., Anne-Sophie Walker, Pierre Leroux, Waard, Maarten A. De, Schoonbeek, Henk-jan, Leroch, Michaela, Leroch, M., Pradier, Jean Marc, Leroux, Pierre, P., Mosbach, A., Waard, M.A., de, Dennis Mernke, Pradier, Jean-Marc, Hahn Matthias, Leroch Michaela, Walker Anne-Sophie, Schoonbeek Henk-Jan, Fillinger-David, Sabine, Helma, Henk-Jan Schoonbeek, Mernke Dennis, Fillinger, Sabine, Mosbach Andreas, Andreas Mosbach, Michaela Leroch, Kretschmer, Matthias, Schoonbeek, H.J., Hahn, M.   +53 more
core   +1 more source