Results 81 to 90 of about 365,847 (307)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
, 1999 Documento en PDF,9 páginas.Mediante este decreto se hace una Reforma Organizativa y Funcional del Ministerio de Obras Públicas y Transportes, entre ellas, se da la creación del Consejo Portuario Nacional, que aunque adscritos o ligados al Ministerio de ...
El Poder Ejecutivo de la República de Costa Rica
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ilness’ perception for truck drivers absented by social security system
Estudos Interdisciplinares em Psicologia, 2016 Objetiva-se compreender o afastamento do trabalho de caminhoneiros de rota longa em benefício previdenciário e com indicação de reabilitação profissional pelo Instituto Nacional do Seguro Social (INSS) visando conhecer como percebiam seu trabalho e os ...
Livia Guimarães Delfino +1 more
doaj +1 more source
China in Latin America: lessons for South-South cooperation and sustainable development [PDF]
, 2015 This repository item contains a report from the Boston University Global Economic Governance Initiative. The Global Economic Governance Initiative (GEGI) is a research program of the Center for Finance, Law & Policy, the Frederick S.
Gallagher, Kevin P. +3 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Rutas de transporte público y situación de la tuberculosis en Lima, Perú
Revista Peruana de Medicina Experimental y Salud PúblicaCon el objetivo de determinar la asociación entre el número de rutas formales de transporte público urbano y la situación de la tuberculosis (TB) en cada distrito de Lima, se realizó un análisis correlacional y un modelo de regresión lineal entre ambas ...
Octavio Garaycochea, Eduardo Ticona
doaj +2 more sources
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Carrier linked solute transport through biomembranes is analysed with the viewpoint of catalysis. Different from enzymes, in carriers the unchanged substrate induces optimum fit in the transition state. The enhanced intrinsic binding energy pays for the energy required of the global conformation changes, thus decreasing the activation energy barrier ...
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source