Results 71 to 80 of about 32,498 (309)

Modelagem espacial e fatores associados aos acidentes de trânsito atendidos pelo Serviço de Atendimento Móvel de Urgência de Arapiraca, AL: estudo ecológico, 2018 [PDF]

open access: yesCadernos de Saúde Coletiva
Resumo Introdução Acidentes de trânsito envolvendo motocicletas representam um grave problema social, econômico e de saúde no Brasil. Objetivo Analisar a distribuição espacial e os fatores associados aos acidentes de trânsito urbanos atendidos pelo ...
Fernanda Mayara Santana   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Novo marco legal das ferrovias: um avanço para o setor de transportes

open access: yes, 2021
O novo marco legal das ferrovias representa um avanço para o setor de transportes e abre grandes possibilidades para investimentos no setor ...
Quintella, Marcus
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

O sistema de transporte de cargas no Brasil e sua influência sobre a economia [PDF]

open access: yes, 2011
TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Economia.Esta pesquisa abordou a matriz de transportes de cargas brasileira, traçando um comparativo entre os principais sistemas utilizados no país, buscando ...
Schmidt, Elcio Luís
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Estratégias competitivas da empresa Três Barras Transportes [PDF]

open access: yes, 2013
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Graduação em Ciências Econômicas.O presente trabalho tem o objetivo de analisar as estratégias competitivas de uma microempresa do setor de transporte rodoviário ...
Brandini, Fábio Antônio
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Mudanças à vista na matriz de transportes de cargas brasileira

open access: yes, 2020
Existem muitos desafios a serem superados na infraestrutura de transporte brasileira, além da necessidade da otimização dos modos de transportes. É nesse cenário que esse artigo analisa as possíveis mudanças na matriz de transportes e as principais ...
Sucena, Marcelo Prado
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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