Results 71 to 80 of about 365,847 (307)

UMA CONTRIBUIÇÃO À SOLUÇÃO DO PROBLEMA DE ROTEAMENTO COM MÚLTIPLOS OBJETIVOS

Transportes, 1995
Este trabalho foi desenvolvido a fim de apresentar soluções para o problema de roteamento com múltiplos objetivos. No intuito de analisar a solução para este tipo de problema foi estudado o caso de sistema de ônibus fretado.
André Tadeu Paes de Souza, Carlos David Nassi   +1 more
doaj   +1 more source

Control de la temperatura en el transporte de alimentos mediante sistemas RFID [PDF]

, 2009
Investigadores de la Universidad Politécnica de Madrid (UPM) y de la Universidad de Bremen (Alemania) trabajan conjuntamente en la supervisión y control de transportes frigoríficos y así poder asegurar la trazabilidad de los productos alimentarios hasta ...
Barreiro Elorza, Pilar, Ruiz García, Luis   +1 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Modelagem espacial e fatores associados aos acidentes de trânsito atendidos pelo Serviço de Atendimento Móvel de Urgência de Arapiraca, AL: estudo ecológico, 2018 [PDF]

Cadernos de Saúde Coletiva
Resumo Introdução Acidentes de trânsito envolvendo motocicletas representam um grave problema social, econômico e de saúde no Brasil. Objetivo Analisar a distribuição espacial e os fatores associados aos acidentes de trânsito urbanos atendidos pelo ...
Fernanda Mayara Santana, Etvaldo Rodrigues da Silva, Diego Santos Albuquerque, Michael Ferreira Machado, Ana Paula Nogueira de Magalhães, Carlos Dornels Freire de Souza   +5 more
doaj   +1 more source

Infraestructura de los transportes [PDF]

, 1983
Fil: Rosman, David Gregorio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra de Política Económica Argentina.
Rosman, David Gregorio
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Metodologia para identificação da qualidade da informação para planejamento de transportes [PDF]

, 2004
No planejamento de transportes são exigidas do planejador ações eficientes e dinâmicas para que os recursos existentes sejam administrados da melhor forma possível.
Correia, Diógenes Eustáquio Rezende, Yamashita, Yaeko   +1 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source