Results 51 to 60 of about 3,135 (212)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Sobre Guillermo Guajardo Soto, Tecnología, Estado y ferrocarriles en Chile, 1850-1950
Historia Mexicana El Colegio de México, 2009 -
Francisco Zapata
doaj
Revista Brasileira de Cineantropometria e Desempenho Humano, 2014 A escola é um local favorável ao desenvolvimento de intervenções para o aumento da atividade física devido à possibilidade de alcançar simultaneamente grande número de indivíduos.
Giovâni Firpo Del Duca +5 more
doaj +1 more source
Inserção da cabotagem no transporte de suprimentos para a 8ª Região Militar
Coleção Meira Mattos, 2020 A navegação de cabotagem é parcela fundamental para a otimização de redes de transportes de grandes volumes de cargas em longas distâncias, com significativo potencial de expansão tendo em vista a extensão da costa marítima brasileira e a dimensão ...
Newton Carlos de Oliveira Portella +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Revista de Administração Pública, 2010 Este artigo apresenta os resultados de uma investigação bibliográfica e documental sobre avaliação econômica de projetos, identificando o estado da arte e as melhores práticas internacionais nessa área, bem como os critérios atualmente adotados no Brasil.
Marta Corrêa Dalbem +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Impact of Costs Related to International Roughness Index Variability on a Brazilian Runway
Journal of Aerospace Technology and ManagementThe functional quality of runways (RWY) is a critical factor for the safety and comfort of airport operations. One of the main indices used to assess this quality is the International Roughness Index (IRI).
José Levi Chaves de Sousa +4 more
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