Results 91 to 100 of about 43,431 (260)

Tailles de villes et coûts de transport [PDF]

open access: yes
Dans cet article, nous démontrons, à partir d'un échantillon de 47 villes françaises, qu'il est douteux que des économies apparaissent dans l'exploitation des transports publics urbains lorsque la taille des villes s'accroît.
Alain Chausse, Dominique Bouf
core  

Etude sur les tendances nocturnes de la ville de Sion: Qu’annonce le crépuscule du soir au coeur du Valais ? [PDF]

open access: yes, 2018
La vie nocturne de la ville de Sion prend vie dès que le soleil s’est couché et se termine dès que ce dernier se lève. Mais que se passe-t-il durant ce lapse de temps et quelle importance faut-il y accorder ?
Luyet, Laura, Zuber, Benoit
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

[Study analysis evaluating the management and epidemiological aspects of the COVID-19 pandemic in Senegal one year on]. [PDF]

open access: yesPan Afr Med J, 2023
Bousso A   +8 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

A responsabilidade civil do estado decorrente da violação ao direito à segurança pública

open access: yesRevista Interdisciplinar de Direito, 2011
Il est debaté dans l’actualité la possibilité d’application du concept de la responsabilité civile au droit administratif devant l’omission de l’État et de la conséquente création d’une expectative legitime par les citoyens d’implementation de certaine ...
Ana Carolina De Nigris   +1 more
doaj  

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

CONTROLER LA QUALITE DES SERVICES PUBLICS : QUELLE PLACE POUR LES USAGERS ?: Etude de deux expériences de collectivités territoriales françaises [PDF]

open access: yes, 2013
International audienceFrench local services analysis shows an increasing interest to service user. Management control systems are developed in order to improve service quality and adaptation to users 'needs. However, user's place is not so obvious.
Ragaigne, Aurélien, Tahar, Caroline
core   +4 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

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