Results 111 to 120 of about 7,396,251 (305)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

A responsabilidade civil do estado decorrente da violação ao direito à segurança pública

open access: yesRevista Interdisciplinar de Direito, 2011
Il est debaté dans l’actualité la possibilité d’application du concept de la responsabilité civile au droit administratif devant l’omission de l’État et de la conséquente création d’une expectative legitime par les citoyens d’implementation de certaine ...
Ana Carolina De Nigris   +1 more
doaj  

Modélisation multi-agents de transports collectifs artisanaux : structures émergentes et stratégies individuelles [PDF]

open access: yes, 2015
International audiencePublic authorities of several metropolises in southern countries do not participate in the management of the collective transports. In this context of lack of centralization, alternative solutions appear.
Wester, Léa
core   +2 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Les conflits d'aménagement, de l'utilité sociale à l'équité locale ? Le calcul économique et les dispositifs juridiques au défi de l'équité dans les nuisances des infrastructures

open access: yes, 2004
Conciliating economic efficiency with equity is a key issue in the implementation of infrastructure-building projects that have public interest content. This issue can be related to another one, i.e.
Kirat, Thierry, Levratto, Nadine
core   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

VTC & PHV, une étude comparative de la manière dont les Anglais régulent l'offre de transports particuliers de personnes [PDF]

open access: yes, 2014
La libre interaction de l'offre et de la demande ne permet pas de réguler le marché du transport particulier de personnes que l'on hèle dans la rue. C'est pourquoi, l'offre de taxis est généralement strictement régulée en prix et en quantité par les ...
Darbéra, Richard
core   +2 more sources

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