Results 91 to 100 of about 7,396,251 (305)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finanzielle Folgen des Schwarzfahrens
sui-generisWer ohne gültigen Fahrschein öffentliche Verkehrsbetriebe benutzt, hat den eigentlichen Fahrpreis und den sog. Zuschlag zu bezahlen. Wer dies wiederholt tut, muss auch noch eine Staffelungsgebühr entrichten. Daneben ist auch eine strafrechtliche Ahndung
Luca Schoop
doaj +1 more source
Etude sur les tendances nocturnes de la ville de Sion: Qu’annonce le crépuscule du soir au coeur du Valais ? [PDF]
, 2018 La vie nocturne de la ville de Sion prend vie dès que le soleil s’est couché et se termine dès que ce dernier se lève. Mais que se passe-t-il durant ce lapse de temps et quelle importance faut-il y accorder ?
Luyet, Laura, Zuber, Benoit
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Transports publics, réseaux de téléphonie mobile et nomadisme : la révolution des NTIC au service du renouveau des transports publics [PDF]
La mobilité est un enjeu essentiel de notre vie quotidienne, principalement en milieu urbain. Elle se définit par une succession de déplacements d'un lieu à un autre, rythmant notre vie comme l'exprime si bien la célèbre rengaine « métro-boulot-dodo ...
Laurent Guihéry
core
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
La sauvegarde des préoccupations d’intérêt général dans le cadre de la régulation économique. En particulier le service postal universel [PDF]
, 2007 Peer ...
Durviaux, Ann Lawrence
core
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source