A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Moving ideas: An agenda for expanding the political scope of the policy mobilities approach. [PDF]
McCann E.
europepmc +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Transport starter data kit: Historical passenger and freight transport data for selected countries in Africa, Asia, and South America. [PDF]
Tan N +7 more
europepmc +1 more source
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy +9 more
wiley +1 more source
Bus-exposure matrix, a tool to assess bus drivers' exposure to physicochemical hazards. [PDF]
Remy VFM +3 more
europepmc +1 more source
Provinces and Territories Are Overdue for an Update in Healthcare Funding Policies. [PDF]
Sutherland JM.
europepmc +1 more source
Le péage de Stockholm : évaluation et enseignement [PDF]
Le péage de Stockholm engendre, comme prévu par la théorie, une réduction du trafic, une augmentation de la vitesse et des gains de temps pour ceux qui continuent d'utiliser leur automobile.
Pierre Kopp, Rémy Prud'Homme
core
Financial Distress and Its Determinants in Rheumatoid Arthritis
Objective To quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease‐modifying therapies. Methods We identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the ...
Amber Brown Keebler +5 more
wiley +1 more source
The promises and perils of a free rural inter-city transportation scheme: A mixed-methods study from Northern Saskatchewan. [PDF]
Alhassan JAK, Fuller D, Woytowich R.
europepmc +1 more source

