Results 41 to 50 of about 43,628 (282)

Des aménagements piétons pour un accès plus attractif aux transports publics ? Une approche comparative franco-tchèque. [PDF]

, 2014
Cette communication s'inscrit dans le champ des recherches portant sur la conception d'espaces urbains à l'échelle de quartier et adaptés à l'usage des transports collectifs, champ habituellement qualifié d'" urbanisme orienté vers les transports ...
Mermet, Samuel, Smida, Jiri, Zelezny, Richard   +2 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Exploitation de l'imagerie Pléiades-THR en cartographie réactive suite à des catastrophes naturelles ayant affecté le territoire français en 2013

Revue Française de Photogrammétrie et de Télédétection, 2015
Dans le cadre de la Recette Thématique Utilisateur pour la valorisation des données Pléiades-THR, des images ont été acquises lors de désastres naturels ou pour des exercices dédiés à la demande des grands services de l'Etat (Ministère de l'Environnement,
Hervé Yésou, Aurélie Escudier, Stéphanie Battiston, Jean-Yves Dardillac, Stephen Clandillon, Carlos Uribe, Mathilde Caspard, Henri Giraud, Jérôme Maxant, Arnaud Durand, Kader Fellah, Mathias Studer, Claire Huber, Laurent Philippoteaux, Paul de Fraipont, Delphine Fontannaz   +15 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Des transports publics pour tous ? Une évaluation des arrêts de la STIB à Bruxelles

Brussels Studies
This paper analyses the state of public transport (PT) stops in Brussels through the lens of inclusiveness for disabled persons. The approach mixes qualitative perspectives (including talks and field trips with numerous NGOs, disabled individuals using ...
Frédéric Dobruszkes, Martin Grandjean, Arthur Nihoul, Julien Descamps   +3 more
doaj   +1 more source

La mairie de Londres: l'exception qui confirme la règle [PDF]

, 2004
Le maire de Londres se fie à l'efficacité lorsque le service répond aux exigences du service citoyen plutôt qu'à des questions de simple rentabilité. Il protège ainsi une certaine éthique du service public et se dresse comme un rempart contre ceux qui ...
Whitton, Timothy
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Vers des transports publics pour tous à Bruxelles : une évaluation de scénarios de design inclusif

Brussels Studies
This paper assesses the impact of 15 scenarios that improve the inclusiveness of the Brussels public transport network in terms of access to the city for disabled people. The scenarios are based on improved designs of surface and underground stops and of
Frédéric Dobruszkes, Martin Grandjean, Arthur Nihoul   +2 more
doaj   +1 more source