Results 91 to 100 of about 2,371,477 (389)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Statistical learning quantifies transposable element-mediated cis-regulation

Genome Biology, 2023
Background Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryogenesis to innate ...
Cyril Pulver, Delphine Grun, Julien Duc, Shaoline Sheppard, Evarist Planet, Alexandre Coudray, Raphaël de Fondeville, Julien Pontis, Didier Trono   +8 more
doaj   +1 more source

Involvement of transposable elements in neurogenesis

Vavilov Journal of Genetics and Breeding, 2020
The article is about the role of transposons in the regulation of functioning of neuronal stem cells and mature neurons of the human brain. Starting from the first division of the zygote, embryonic development is governed by regular activations of transposable elements, which are necessary for the sequential regulation of the expression of genes ...
R. N. Mustafin, E. K. Khusnutdinova
openaire   +4 more sources

Tracking the origin of two genetic components associated with transposable element bursts in domesticated rice

Nature Communications, 2019
Transposable elements (TEs) shape genome evolution through periodic bursts of amplification. In this study prior knowledge of the mPing/Ping/Pong TE family is exploited to track their copy numbers and distribution in genome sequences from 3,000 ...
Jinfeng Chen, Lu Lu, Jazmine Benjamin, Stephanie Diaz, C. N. Hancock, J. Stajich, S. Wessler   +6 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome

Mobile DNA, 2019
Background Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of structural variation and somatic mutation. To this end, laboratories have developed
Jared P. Steranka, Zuojian Tang, Mark Grivainis, Cheng Ran Lisa Huang, Lindsay M. Payer, Fernanda O. R. Rego, Thiago Luiz Araujo Miller, Pedro A. F. Galante, Sitharam Ramaswami, Adriana Heguy, David Fenyö, Jef D. Boeke, Kathleen H. Burns   +12 more
doaj   +1 more source

Transposable element subfamily annotation has a reproducibility problem

Mobile DNA, 2021
Background Transposable element (TE) sequences are classified into families based on the reconstructed history of replication, and into subfamilies based on more fine-grained features that are often intended to capture family history.
Kaitlin M. Carey, Gilia Patterson, Travis J. Wheeler   +2 more
doaj   +1 more source

Length enumeration of fully commutative elements in finite and affine Coxeter groups [PDF]

J. Algebra, 513 (2018) 466-515, 2016
An element w of a Coxeter group W is said to be fully commutative, if any reduced expression of w can be obtained from any other by transposing adjacent pairs of generators. These elements were described in 1996 by Stembridge in the case of finite irreducible groups, and more recently by Biagioli, Jouhet and Nadeau (BJN) in the affine cases.
arxiv   +1 more source

Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila

bioRxiv, 2018
Mapping genotype to phenotype is challenging because of the difficulties in identifying both the traits under selection and the specific genetic variants underlying these traits. Most of the current knowledge of the genetic basis of adaptive evolution is
G. Rech, María Bogaerts-Márquez, Maite G. Barrón, Miriam Merenciano, J. L. Villanueva-Cañas, V. Horváth, Anna-Sophie Fiston-Lavier, Isabelle Luyten, S. Venkataram, H. Quesneville, D. Petrov, Josefa González   +11 more
semanticscholar   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source