Results 71 to 80 of about 2,609,081 (310)

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

Transposable element-medicated evolution of sex: A population genetic model

, 1990
For a population made up of individuals capable of sexual as well as asexual modes of reproduction, conditions for the spread of a transposable element are explored using a one-locus, two-haplotype model.
Joshi, NV
core   +2 more sources

Dynamics of Transposable Element Invasions with piRNA Clusters

bioRxiv, 2018
In mammals and in invertebrates the proliferation of a newly invading transposable element (TE) is thought to be stopped by a random insertion of one member of the invading TE family into a piRNA cluster. This view is known as the trap model.
R. Kofler
semanticscholar   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Whole genome duplication and transposable element proliferation drive genome expansion in Corydoradinae catfishes [PDF]

, 2018
Genome size varies significantly across eukaryotic taxa and the largest changes are typically driven by macro-mutations such as whole genome duplications (WGDs) and proliferation of repetitive elements.
Simon Creer, Taylor, Martin I, Sarah Marburger, Martin I. Taylor, Alexandrou, Markos A., Alexandrou, Markos A, Oliveira, Claudio [UNESP], Claudio Oliveira, Markos A. Alexandrou, Taggart, John B, Gary Carvalho, Marburger, Sarah, Oliveira, Claudio, Carvalho, Gary, Taggart, John B., Taylor, Martin I., Creer, Simon, Alexandrou, Markos, John B. Taggart   +18 more
core   +1 more source

Molecular dissection of a natural transposable element invasion

Genome Research, 2018
The first tracking of the dynamics of a natural invasion by a transposable element (TE) provides unprecedented details on the establishment of host defense mechanisms against TEs. We captured a D.
R. Kofler, Kirsten-André Senti, V. Nolte, R. Tobler, C. Schlötterer   +4 more
semanticscholar   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila

bioRxiv, 2018
Mapping genotype to phenotype is challenging because of the difficulties in identifying both the traits under selection and the specific genetic variants underlying these traits. Most of the current knowledge of the genetic basis of adaptive evolution is
G. Rech, María Bogaerts-Márquez, Maite G. Barrón, Miriam Merenciano, J. Villanueva-Cañas, V. Horváth, Anna-Sophie Fiston-Lavier, Isabelle Luyten, S. Venkataram, H. Quesneville, D. Petrov, Josefa González   +11 more
semanticscholar   +1 more source

Discordance Between Systemic Lupus Erythematosus Disease Activity Index Domain Weights and Their Association With Organ Damage Accrual

Arthritis Care &Research, EarlyView.
Objective Studies of damage accrual in patients with systemic lupus erythematosus (SLE) show associations with disease activity measured by the SLE Disease Activity Index 2000 (SLEDAI‐2K), but these associations are imperfect. SLEDAI scores are powerfully influenced by weightings (1–8) assigned to each domain.
Kevin Zhang, Eric F. Morand, Sarah E. Boyd, François Petitjean, Alberta Hoi, Rachel Koelmeyer, Iolanda Miceli, Julie A. Monk, Hieu T. Nim   +8 more
wiley   +1 more source

Transposable element detection and annotation in Microbotryum species genomes

, 2023
gff3 files of transposable element sequences detected in the haploid genomes of 16 Microbotryum species (two strains of M. lychnidis dioicae) as well as a red yeast (Rhodothorula babjavae), for each mating type, using https://gitlab.com/marine.c.duhamel ...
Marine Duhamel (13340610)
core   +1 more source