Results 61 to 70 of about 1,813,007 (299)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Due to Rare Transposable Element Insertion Alleles of Large Effect [PDF]
, 2014 Transposable elements are a common source of genetic variation that may play a substantial role in contributing to gene expression variation. However, the contribution of transposable elements to expression variation thus far consists of a handful of ...
Long, Anthony D +5 more
core +1 more source
Mobile DNA, 2019 Background Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of structural variation and somatic mutation. To this end, laboratories have developed
Jared P. Steranka +12 more
doaj +1 more source
PLoS ONE, 2021 Alternative splicing of the gene MAPT produces several isoforms of tau protein. Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases.
Jennifer Grundman +3 more
doaj +1 more source
Homotypic Transposable Element Pairing May Drive Coherent Chromatin Folding. [PDF]
Genes (Basel)Background/Objectives: Transposable elements comprise over 50% of the human genome, yet their role in chromatin organization is insufficiently studied. This study was motivated by the hypothesis that transposable elements drive chromatin contacts through
Myakishev-Rempel M.
europepmc +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The effects of foreign genes in transgenic Thale cress (Arabidopsis thaliana [PDF]
, 1991 Agrobacterium tumefaciens-mediated transformation was used to introduce foreign genes into Arabidopsis thaliana (Thale Cress). Initially a simple marker gene construct (pJIT73) was used to set up the transformation system. Once established, three further
Evans, Katherine Mary, Evans, K.M
core
Transposable element-medicated evolution of sex: a population genetic model [PDF]
, 1990 For a population made up of individuals capable of sexual as well as asexual modes of reproduction, conditions for the spread of a transposable element are explored using a one-locus, two-haplotype model.
Joshi, N. V.
core +2 more sources
Nature CommunicationsTransposable elements are abundant in the human genome and have been increasingly recognized as sources of alternative promoters. Yet, the extent of their transcriptional activity in human tissues and the features that govern their regulatory potential ...
Ya Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source