Results 221 to 230 of about 77,105 (268)

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease. [PDF]

Front Mol Biosci
Fan X, Deng S, Xu Y, Wang B, Guo X, Liao J, Xu M.   +6 more
europepmc   +1 more source

Development of Ac- and Ds-tagged starter lines for large-scale transposon-mutagenesis in tomato. [PDF]

PLoS One
Kumari A, Ponukumatla R, Pandey AK, Sreelakshmi Y, Sharma R.   +4 more
europepmc   +1 more source

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Transposase–Transposase Interactions in MOS1 Complexes: A Biochemical Approach

Journal of Molecular Biology, 2011
Transposases are proteins that have assumed the mobility of class II transposable elements. In order to map the interfaces involved in transposase-transposase interactions, we have taken advantage of 12 transposase mutants that impair mariner transposase-transposase interactions taking place during transposition.
Guillaume, Carpentier, Jérome, Jaillet, Aude, Pflieger, Jérémy, Adet, Sylvaine, Renault, Corinne, Augé-Gouillou   +5 more
openaire   +2 more sources

Capturing transposases for new proteins

Nature Reviews Genetics, 2021
A new study by Cosby et al., investigating the role of DNA transposable elements in exon shuffling, reports that transposase capture is a recurrent process in evolution underlying the origin of new regulators of gene expression.
openaire   +2 more sources

Integrating DNA: Transposases and Retroviral Integrases

Annual Review of Microbiology, 1999
▪ Abstract  Transposable elements appear quite disparate in their organization and in the types of genetic rearrangements they promote. In spite of this diversity, retroviruses and many transposons of both prokaryotes and eukaryotes show clear similarities in the chemical reactions involved in their transposition.
L, Haren, B, Ton-Hoang, M, Chandler
openaire   +2 more sources

Tn5 Transposase

2023
Tn5 Transposase is an enzyme that binds to the end of a transposon and catalyzes its movement to another part of the genome by a cut-and-paste mechanism or a "replicative transposition mechanism. Genes encoding transposases are widespreadthe most abundant in the genomes of most organisms and are the most abundant genes known.
openaire   +1 more source

Evidence for “Unseen” Transposase–DNA Contacts

Journal of Molecular Biology, 2002
In this study, evidence of novel, important interactions between a hyperactive Tn5 transposon recognition end sequence and hyperactive Tn5 transposase (Tnp) are presented. A hyperactive Tn5 end sequence, the mosaic end (ME), was isolated previously.
Mindy, Steiniger-White, Archna, Bhasin, Scott, Lovell, Ivan, Rayment, William S, Reznikoff   +4 more
openaire   +2 more sources

Transposase-driven rearrangements in human tumors

Nature Genetics, 2017
A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.
Stephen C, Mack, Hiromichi, Suzuki, Michael D, Taylor   +2 more
openaire   +2 more sources