Results 231 to 240 of about 68,477 (364)

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

331. Novel Enhanced Transposases Result in Robust Stable Gene Transfer into Hematopoietic, Mesenchymal and Muscle Stem/Progenitor Cells Ex Vivo and Hepatocytes In Vivo [PDF]

, 2008

openalex   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers. [PDF]

Development
Kawaguchi A, Igari M, Murayama Y, Iikawa H, Sakamoto M, Nakamura Y, Kuraku S, Ishihara K, Saito D.   +8 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, Volume 13, Issue 33, 15 June 2026.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Deciphering the drivers of antibiotic resistance gene transmission in the megacity: Co-occurring contaminants and bacterial community. [PDF]

Eco Environ Health
Ding F, Li Y, He T, Wang Y, Li Y, Huang Y, Yin G, Yang J, Liu Y, Li Y, Li T, Hou L, Liu M.   +12 more
europepmc   +1 more source

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1

, 2006
Oliver Walisko, Zsuzsanna Izsvák, Kornélia Szabó, Christopher D. Kaufman, Steffi Herold, Zoltán Ivics   +5 more
openalex   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

Assessment of Ubiquitous Promoters Driving Fluorescent Marker and Transposase Expression to Develop a High-Performance <i>piggyBac</i> Transgenic System in <i>Bactrocera dorsalis</i>. [PDF]

Insects
Jiang H, Wu Y, Cai J, Lin X, Yan R.
europepmc   +1 more source

Mutations in the mariner transposase: The D,D(35)E consensus sequence is nonfunctional

, 1997
Allan R. Lohe, Daniel De Aguiar, Daniel L. Hartl   +2 more
openalex   +2 more sources