Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Ministerial Transposition of EU Directives: Can Oversight Improve Performance? [PDF]
This paper argues that the extent to which national administrations transpose EU directives in a timely fashion may be related to how transposition is coordinated inside national ministries.
Katarina Staronova, Radoslaw Zubek
core
Michael Christoforidis & Elizabeth Kertesz, Carmen and the Staging of Spain. Recasting Bizet’s Opera in the Belle Époque [PDF]
, 2019 Since its Parisian premiere in 1875, few operas have managed to have the same far-reaching impact across the world as Bizet’s Carmen. Co-authored by Michael Christoforidis and Elizabeth Kertesz (both based at the University of Melbourne), the book ...
San Martín Arbide, Lola +1 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Repenser la musicologie au sein des sciences humaines [PDF]
, 2018 À ceux qui traditionnellement mettent en doute la musicologie, proposons une réponse précise : nous musicologues cherchons par tous les moyens à comprendre comment et pourquoi l’homme a toujours et partout estimé si important de créer des formes ...
Anne-Sylvie Barthel-Calvet +1 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Taking stock: a review of quantitative studies of transposition and implementation of EU law [PDF]
This paper presents a literature review of all quantitative (statistical) studies of compliance with EU law. The paper introduces and makes use of a new online database http://www.eif.oeaw.ac.at/implementation/ which presents a detailed and comprehensive
Dimiter Toshkov
core
Création musicale, World Music et diversité culturelle : la musique comme outil d’intelligibilité anthropologique [PDF]
, 2018 Faire de la musique un outil d’intelligibilité anthropologique, telle est l’ambition de ce séminaire que Denis Laborde porte depuis une vingtaine d’années à l’EHESS. Ambiance campus international.
Laborde, Denis, Denis Laborde
core +1 more source
Contextualisation didactique : un concept en tension ?
Contextes et Didactiques, 2019 This article proposes a viewpoint about reflections that have been going on for ten years, particularly in the research and resource center for education and training, a research unit at the University des Antilles.
Antoine Delcroix
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source