Results 151 to 160 of about 135,062 (303)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Gamification, collaborative learning and transversal competences: analysis of academic performance and students’ perceptions

Smart Learning Environments
The importance and benefits of teamwork in the university context have been widely recognized in recent decades. However, there is little evidence that analyzes the effects of the combination of collaborative learning strategies and gamification ...
Cecilia Latorre-Cosculluela, Verónica Sierra-Sánchez, Sandra Vázquez-Toledo   +2 more
doaj   +1 more source

Empowering Employability through Transversal Skills and Competencies

Norsk IKT-konferanse for forskning og utdanning
In response to the evolving demands of the labor market, Higher Education Institutions (HEIs) increasingly emphasize the development of Transversal Skills and Competences (TSC). This study contributes to the dialogue on aligning academic curricula in a bachelor’s degree in computer science with professional needs through collaborative efforts.
Grethe Sandstrak, Bjørn Klefstad
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

COMPETENCES ACQUIRED BY GRADUATES THROUGH MARKETING HIGHER EDUCATION - FINDINGS FROM THE EMPLOYERS' PERSPECTIVE [PDF]

The primary purpose of the economic higher education in providing the graduates with marketing competences is to train them for employment. In light of the said objective, two important aspects must be taken into account by educators.
Babut Raluca, Dabija Dan Cristian, Plaias Ioan, Pop Ciprian Marcel   +3 more
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

COMPETENŢA – ABORDARE SITUAŢIONALĂ, STRUCTURALĂ ŞI METODOLOGICĂ

Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2018
În articol este analizată problema „competenţelor” din diferite perspective: clarificărilor conceptuale, abordărilor situaţională şi structurală, metodologică şi acțională.
Vladimir GUŢU
doaj  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Key Competences in Europe: Opening Doors For Lifelong Learners Across the School Curriculum and Teacher Education [PDF]

The aim of the study is to provide a comparative overview of policy and practice concerning the development and implementation of key competences in the education systems of the 27 Member States of the European Union.
Alain Michel, David Pepper, Elzbieta Putkiewicz, Gabor Halasz, Jean Gordon, Jerzy Wisniewski, Magdalena Krawczyk, Tom Leney   +7 more
core