Results 61 to 70 of about 18,049 (290)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Comprehension in Preschool of Developing Transversal Self-Regulated Learning Skills

open access: yes, 2020
Maģistra darbs „Pašvadītās mācīšanās izpratne caurviju prasmju attīstībā pirmsskolā” pēta Latvijas pirmsskolas izglītības iestāžu izpratni par pašvadītu mācīšanos teorētiskā un praktiskā līmenī caurviju prasmju kontekstā. 2019.
Rulle, Ieva
core   +1 more source

Impact of Teaching and Learning Modes on Graduates’ Social and Entrepreneurial Skills Development: A Comparative Analysis

open access: yesEducation Sciences
There is a growing interest in researching the impact of different modes of learning and teaching on the non-academic outcomes of graduates, such as their employment outcomes. This study examines the impact of teaching and learning modes on the perceived
Ana Tecilazić   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The Impact of Transversal Skills on the Efficiency and Adaptability of the Workforce in the IT Industry [PDF]

open access: yesRevista de Management Comparat International
The IT industry is characterized by an accelerated pace of technological innovation and a high degree of uncertainty, which requires employees not only to master technical skills, but also to develop transversal skills that support their performance ...
Carmen Valentina RADULESCU   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transversal complex simulation program to improve communication skills in dentistry

open access: yes, 2023
Simulation is an effective teaching methodology that allows students to experiment, learn from mistakes, and gain experience in a risk-free environment.
Flacco, Nicla   +4 more
core   +1 more source

Holistic Intelligence: Transversal Skills a Current Methodologies [PDF]

open access: yesProceedings of the 2nd Conference on Artificial General Intelligence (2009), 2009
Certain necessary features of general intelligence are more system-wide than others; features such as attention, learning and temporal grounding are transversal in that they seem to affect a significant subset of all mental operation. We argue that such transversal features unavoidably impose fundamental constraints on the kinds of architectures and ...
Eric Nivel, Kristinn R. Thorisson
openaire   +1 more source

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