Results 81 to 90 of about 135,062 (303)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The Technology of Development of Transversal Skills of Future Philologists in the Process of Distance Learning in the Online Course “Effective Communication”

open access: yesInternational Journal of Research in E-Learning, 2019
The article is devoted to an important problem in the higher educational system, namely, the presentation of the technology of development of transversal skills of future philologists in the process of distance learning in the online course “Effective ...
Tetiana Simonenko, Yulia Nikitska
doaj   +1 more source

A Capacity Building for Higher Education ERASMUS+ Project: Strategic Human Resources Management for Southeast Asian Universities (HR4ASIA) [PDF]

open access: yes, 2018
The development and optimization of Higher Education Institutions (HEIs) is becoming more and more important. Consequently, Human Resources Management (HRM) has gained greater prominence in the management of these institutions.
Chuong, T.   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Assessing the relevance of higher education courses [PDF]

open access: yes, 2007
The establishment of the European Higher Education Area has involved specifying lists of professional competencies that programs are expected to develop, and with this the need for procedures to measure how every course within a higher education program ...
Gil, Francisco   +6 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

THE MEANING OF TRANSVERSAL SKILLS IN ECONOMICS EDUCATION

open access: yesEducation. Innovation. Diversity
The article highlights the significance of transversal skills in economics education for enhancing financial literacy. The publication emphasizes the importance of combining theoretical understanding with practical knowledge to improve individual financial literacy, which contributes to fostering national economic growth.
Juris Straume   +2 more
openaire   +1 more source

Regionalization and harmonization in TVET [PDF]

open access: yes, 2017
A transversal skill is one of the skills needed in every type of workplace setting. There is limited information about the perceptions of which transferable skills are needed in the workplace.
Bukit, M.   +7 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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